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Drug-induced fulminant hepatic failure in pregnancy

机译:怀孕的药物诱导的急性肝衰竭

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Liver disease in pregnancy can be classified as predating, co-incidental or unique to pregnancy. Medications are often overlooked as a significant cause of liver disease. We present the case of a 39-year-old patient who presented at 20 weeks with jaundice, elevated liver enzymes, and abnormal liver function progressing eventually to fulminant hepatic failure. The patient was on methyldopa and labetalol from 12 weeks’ gestational age. Liver biopsy was consistent with drug-induced liver injury. Both methyldopa and labetalol have been associated with hepatotoxicity including liver failure. This case highlights the importance of including medications as a cause of liver failure in pregnant patients.
机译:妊娠期肝病可以被归类为怀孕,共同偶然或独特的妊娠。 药物通常被视为肝病的重要原因。 我们展示了一名39岁的患者,患有黄疸,肝脏升高,肝脏升高,肝功能异常肝功能急性肝功能衰竭。 患者在12周的胎龄的甲醛和唇肠上。 肝脏活组织检查与药物诱导的肝损伤一致。 甲醛和樟本子均与肝毒性有关,包括肝衰竭。 这种情况突出了包括药物作为孕妇肝功能衰竭的原因的重要性。

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