...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BJU international >Bladder outlet obstruction accelerates bladder carcinogenesis.
【24h】

Bladder outlet obstruction accelerates bladder carcinogenesis.

机译：膀胱出口梗阻加速膀胱癌变。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To examine the correlation between partial bladder outlet obstruction (PBOO) and bladder carcinogenesis. MATERIALS AND METHODS: Female Wistar rats (6 weeks old) were divided into three groups of 10 each: group 1 was exposed to n-butyl-n-butanol nitrosamine (BBN, a carcinogen) in drinking water for 8 weeks; group 2 had PBOO induced surgically after exposure to BBN for 8 weeks; group 3 had a sham operation and the rats drank normal water (control group). After 20 weeks, all of the rats were killed humanely and their bladders analysed. RESULTS: There were no significant differences in body weight among the groups. The bladder weight of group 2 was significantly greater than either group 1 or group 3. Histopathologically, bladder smooth muscle hypertrophy was the major cause of the increased bladder weight for group 2. In group 2 there were increases in bladder wall thickness and many nipple-shaped urothelial tumours. Basic fibroblast growth factor and hypoxia-inducible factor-1alpha expression were significantly greater in group 2 than in groups 1 and 3. CONCLUSIONS: Exposure of the bladder to carcinogens during bladder hyperplasia and hypertrophy induced by PBOO results in a greater incidence of superficial bladder carcinoma.
机译：目的：探讨部分膀胱出口梗阻（PBOO）与膀胱癌发生的相关性。材料与方法：将雌性Wistar大鼠（6周龄）分为三组，每组10只：第1组在饮用水中暴露于正丁基-正丁醇亚硝胺（BBN，一种致癌物）中，持续8周。第2组在接触BBN 8周后进行了PBOO手术治疗。第3组假手术，大鼠喝正常水（对照组）。 20周后，将所有大鼠人道地处死并分析其膀胱。结果：各组之间的体重没有显着差异。第2组的膀胱重量明显大于第1组或第3组。组织病理学上，膀胱平滑肌肥大是第2组膀胱重量增加的主要原因。在第2组中，膀胱壁厚度增加并且许多乳头-形尿路上皮肿瘤。第2组中碱性成纤维细胞生长因子和缺氧诱导因子-1α的表达明显高于第1和第3组。结论：膀胱增生和PBOO引起的肥大过程中，暴露于致癌物的膀胱导致浅表性膀胱癌的发生率更高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号