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首页> 外文期刊>Oncology: International Journal of Cancer Research and Treatment >Prognostic Significance of PD-1, PD-L1 and CD8 Gene Expression Levels in Gastric Cancer
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Prognostic Significance of PD-1, PD-L1 and CD8 Gene Expression Levels in Gastric Cancer

机译：PD-1，PD-L1和CD8基因表达水平在胃癌中的预后意义

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Introduction:Anti-programmed cell death 1 (PD-1) therapies have shown promising clinical activity against gastric cancer (GC). We evaluated the clinical significance of immune-related gene expression in GC tissues to better understand the tumor immune microenvironment.Methods:PD-1,PD-1 ligand 1 (PD-L1)andCD8mRNA levels and clinicopathological factors, including survival, were examined by quantitative RT-PCR in 155 GC patients who underwent surgery. PD-1 and PD-L1 expression in tumor tissue from 24 GC patients was investigated by immunohistochemical analysis.Results:PD-1,PD-L1andCD8mRNA levels were significantly lower in tumor tissue than in normal tissue (p< 0.0001,p< 0.05, andp< 0.0001). GC patients with lowPD-1,PD-L1andCD8mRNA levels had significantly poorer overall survival (OS) than those with highPD-1,PD-L1andCD8mRNA levels, respectively (p< 0.001,p< 0.01 andp< 0.05). LowPD-1,PD-L1andCD8mRNA levels were more significantly associated with poor prognosis in undifferentiated-type GC patients than in differentiated-type GC patients (PD-1: differentiatedp =0.0071 vs. undifferentiatedp =0.0024;PD-L1:p =0.6527 vs.p< 0.0001;CD8:p =0.4465 vs.p< 0.05). Multivariate analysis showed that lymph node metastasis, peritoneal dissemination, distant metastasis, lowPD-1mRNA levels and lowCD8mRNA levels were independent prognostic factors for worse OS (lowPD-1mRNA level: OR 2.16, 95% CI 1.10-4.58,p< 0.05; lowCD8mRNA level: OR 2.55, 95% CI 1.12-6.90,p< 0.05).PD-1andPD-L1mRNA levels in immune cells were significantly associated with PD-1 and PD-L1 protein levels (bothp< 0.05), respectively.Conclusions:PD-1,PD-L1andCD8mRNA levels may reflect antitumor immunity in GC, and lowPD-1andCD8mRNA levels are potential predictive biomarkers for poor prognosis in GC patients who underwent surgery.
机译：简介：抗程序化细胞死亡1（PD-1）疗法显示出对胃癌（GC）的临床活性。我们评估了GC组织中免疫相关基因表达的临床意义，以更好地了解肿瘤免疫微环境。方法：PD-1，PD-1配体1（PD-L1）和临床病理因子，包括存活，包括存活，包括存活在155例GC患者中进行的定量RT-PCR接受手术。通过免疫组织化学分析研究了来自24个GC患者的肿瘤组织中的PD-1和PD-L1表达。结果：PD-1，肿瘤组织中PD-1，PD-L1ANDCD8MRNA水平显着低于正常组织（P <0.0001，P <0.05， ANDP <0.0001）。 GC患者PADPD-1，PD-L1ANDCD8MRNA水平显着较差，整体存活率显着较差（OS），分别比HIGHPD-1，PD-L1ANDCD8MRNA水平分别较差（P <0.001，P <0.01 ANDP <0.05）。 LowPD-1，PD-L1Andcd8MRNA水平比未分化的GC患者预后差比在分化型GC患者中更显着相关（PD-1：分化= 0.0071 Vs.未分化化= 0.0024; PD-L1：P = 0.6527 Vs .p <0.0001; CD8：P = 0.4465 Vs.p <0.05）。多变量分析表明，淋巴结转移，腹膜传播，远处转移，LowPD-1MRNA水平和低核效率是较差的OS（LowPD-1MRNA水平：或2.16,95％CI 1.10-4.58，P <0.05; Lowcd8mRNA水平的独立预后因子：或2.55,95％CI 1.12-6.90，P <0.05）。免疫细胞中的pd-1andpd-l1mRNA水平分别与pd-1和pd-l1蛋白水平显着相关（thisp <0.05）。结论：pd-如图1所示，PD-L1AndcD8MRNA水平可能反映GC中的抗肿瘤免疫力，LowPD-1和Cd8mRNA水平是潜在的预测生物标志物，用于治疗手术的GC患者的预测不良。

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