...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reproductive toxicology >Retinoic acid signaling in ovarian folliculogenesis and steroidogenesis
【24h】

Retinoic acid signaling in ovarian folliculogenesis and steroidogenesis

机译：卵巢卵泡发生和甾体制性的维甲酸信号传导

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Retinoids are essential for reproduction. Most research has focused on the role of retinoic acid signaling in the regulation of meiosis during early fetal germ cell development. However, less attention has been paid to the possible effects of retinoic acid signaling in adult female gonads. Retinoic acid, its receptors, and the key enzymes required for retinoic acid synthesis are expressed in the ovaries and they are involved in the regulation of folliculogenesis and steroidogenesis. Exposure to compounds that can interfere with normal retinoic acid signaling is associated with adverse ovarian outcomes, including altered steroidogenesis and reduction in indicators of ovarian reserve in women and laboratory animal models. These observations call for more attention to retinoids as regulators of adult ovarian physiology and as possible targets of endocrine disruption by environmental chemicals. In this review, we summarize the current knowledge of retinoids in folliculogenesis and steroidogenesis in post-pubertal mammalian ovaries.
机译：无鳞状物对繁殖至关重要。大多数研究专注于维托酸信号传导在早期胎生细胞发育中减数分裂调控中的作用。然而，对成年女性性腺中的视黄酸信号传导的可能影响较少。视黄酸，其受体和视黄酸合成所需的关键酶在卵巢中表达，它们参与了毛囊发生和甾体制性的调节。暴露于可以干扰正常的视黄酸信号传导的化合物与不良卵巢成果有关，包括改变的雌激素和妇女和实验室动物模型中卵巢储备的指标。这些观察结果要求更多地关注随着成人卵巢生理学的调节因子，以及环境化学品的内分泌破坏的靶标。在本综述中，我们总结了毛细胞生殖器发生的当前对黄萎病哺乳动物卵巢卵巢发生中的类化合物和甾体系的知识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号