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Organochlorine pesticide exposure in mothers and neural tube defects in offsprings

机译:在母亲和后代神经管缺陷中有机氯杀虫剂暴露

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We explored the association between maternal exposure to organochlorine pesticides and neural tube defects (NTDs) in the offspring. Blood was collected from 35 mothers and their offsprings with NTDs (case group) and from 35 mothers-neonate dyads without congenital anomalies (control group). The median blood levels of DDE, t-HCH and endosulphan in mothers in the case group and of dichlorodiphenyl-trichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), total hexachlorocyclohexane (t-HCH) and endosulfan in the neonates with NTDs were significantly higher. Neonates with NTDs had 3.6 times more chances of having blood levels of endosulfan above the median level of the control group. Mothers delivering offsprings with NTDs had 11.3 times greater chances of having DDE levels above the median concentration in the control group. We recommend a restrained use of organochlorine pesticides like DDT, DDE, and endosulfan, while monitoring the expectant mothers closely for birth defects like NTDs. (C) 2016 Elsevier Inc. All rights reserved.
机译:我们探讨了后代母体暴露于有机氯杀虫剂和神经管缺陷(NTDS)之间的关联。从35名母亲和他们的中间收集血液,并用NTDS(案例组)和35名母亲 - 新生儿二元,没有先天性异常(对照组)。在壳体组和二氯二苯基 - 三氯乙烷(DDT),二氯二苯基 - 三氯乙烯(DDE),NTD中的新生儿中,二氯二苯基 - 三氯乙烯(DDT),全六氯环己烷(T-HCH)和硫醇中的DDE,T-HCH和二硫酸二氯乙烯(DDE),总六氯己烷(T-HCH)和硫丹的中位数显着提高。 Neonates与NTDS具有3.6倍,在对照组中高于中位水平以上的血清含水水平的可能性更多。母亲携带NTDS的后代具有11.3倍的较高机会,在对照组中的中值浓度高于中位数。我们建议使用患有DDT,DDE和硫丹这样的有机氯杀虫剂的受限制使用,同时监测预期母亲,仔细监测出生缺陷,如NTDS。 (c)2016年Elsevier Inc.保留所有权利。

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