...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oncology letters >Role of regulatory T cells and CD8(+) T lymphocytes in the dissemination of circulating tumor cells in primary invasive breast cancer
【24h】

Role of regulatory T cells and CD8(+) T lymphocytes in the dissemination of circulating tumor cells in primary invasive breast cancer

机译：调节性T细胞和CD8（+）T淋巴细胞在原发性侵袭性乳腺癌中循环肿瘤细胞传播中的作用

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Circulating tumor cells (CTCs) dissemination is involved in tumor metastasis and is an independent prognostic factor in patients with primary and metastatic breast cancer. Regulatory T cells (Tregs) and cluster of differentiation (CD)8(+) T lymphocytes are the main types of immune cells in the tumor microenvironment and exert opposite roles on the progression and outcome of breast cancer. The aim of the present study was to evaluate the associations between CTCs and intratumoral/peritumoral Tregs and CD8(+) T lymphocytes in breast cancer. Peripheral CTCs were detected by a multi-marker quantitative polymerase chain reaction platform in 167 patients with invasive breast cancer. Intratumoral/peritumoral Tregs and CD8(+) T lymphocytes were assessed by immunohistochemistry in 167 patients with invasive breast cancer to establish an association between these cell types and detection of peripheral CTCs. CTCs were detected in 55% of the patients with breast cancer. The prevalence of CTCs was positively associated with the number of intratumoral (P=0.002) and peritumoral Tregs (P=0.045), and the primary tumor size (P=0.012). This result was verified by analyzing intratumoral Tregs (P=0.044) and primary tumor size (P=0.044) with multivariate analysis, which indicated that the CTC-positive rate increased with an increasing number of intratumoral Tregs and a larger tumor size In the multivariate analysis, other variables including menopause, tumor-node-metastasis stage and peritumoral Tregs were not associated with the prevalence of CTCs. The prevalence of CTCs was inversely and weakly associated with the number of peritumoral CD8(+) T lymphocytes using the univariate analysis, however this result was not statistically significant (P=0.470). In conclusion, regulatory T cells and CD8(+) T lymphocytes may be involved, at least in part, in the CTCs dissemination of breast cancer, whereby Tregs appear to exert the dominant effect. Furthermore, the role of Tregs in the progression of breast cancer may be mediated by suppressing the dissemination of CTCs, which is primarily determined by intratumoral Tregs.
机译：循环肿瘤细胞（CTCS）散发参与肿瘤转移，是患有原发性和转移性乳腺癌患者的独立预后因素。调节性T细胞（Tregs）和分化簇（CD）8（+）T淋巴细胞是肿瘤微环境中免疫细胞的主要类型，并对乳腺癌的进展和结果发挥相反的作用。本研究的目的是评估CTCS和肿瘤内/腹腔内Tregs和CD8（+）T淋巴细胞在乳腺癌中的关联。在167例侵入性乳腺癌患者中，通过多标记定量聚合酶链反应平台检测外周CTC。通过免疫组织化学在167例侵入性乳腺癌患者中评估肿瘤内/腹部Tregs和CD8（+）T淋巴细胞，以建立这些细胞类型与外周CTC的检测之间的关联。在55％的乳腺癌患者中检测到CTCs。 CTCs的患病率与肿瘤内（P = 0.002）和Peritumoral Tregs（P = 0.045）和初级肿瘤大小（P = 0.012）呈正相关。通过分析具有多变量分析的肿瘤内Tregs（P = 0.044）和原发性肿瘤大小（p = 0.044）来验证该结果，这表明CTC阳性率随着肿瘤瘤的数量增加而增加，多元化分析，其他变量，包括更年期，肿瘤节点转移阶段和腹膜特雷格与CTCs的患病率无关。 CTC的患病率与使用单变量分析的腹部CD8（+）T淋巴细胞的数量呈逆向和弱相关，但是该结果在统计学上没有统计学意义（P = 0.470）。总之，调节性T细胞和CD8（+）T淋巴细胞至少部分地参与乳腺癌的CTCS传播，从而Tregs似乎施加显性效果。此外，可以通过抑制CTC的传播来介导乳腺癌进展中Tregs在乳腺癌进展中的作用，其主要由肿瘤内Tregs测定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号