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首页> 外文期刊>Ocular oncology and pathology. >Atypical Presentation of Bilateral Retinoblastoma with Floaters and Sub-Internal Limiting Membrane Seeds in an 11-Year-Old Asian Indian Male
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Atypical Presentation of Bilateral Retinoblastoma with Floaters and Sub-Internal Limiting Membrane Seeds in an 11-Year-Old Asian Indian Male

机译：在11岁的亚洲印度男性中，双侧视网膜母细胞瘤的非典型视网膜母细胞瘤及亚内部限制膜籽

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Purpose: To report bilateral retinoblastoma in an 11-year-old child presenting with floaters and sub-internal limiting membrane (sub-ILM) seeds. Method: An 11-year-old child presented with floaters of 4 months’ duration. Examination revealed circumscribed, whitish, subhyaloid, floccular nodules in the juxtapapillary region of both eyes. No solid tumor was seen. Swept-source optical coherence tomography revealed moderately reflective echoes in the sub-ILM space. Vitreous aspiration of sub-ILM deposits and cytopathological examination revealed retinoblastoma. Intravitreal melphalan (20 μg/0.02 mL) was followed by 6 monthly cycles of high-dose systemic chemotherapy (vincristine, etoposide, carboplatin). Metastatic workup and genetic testing for RB1 mutational screening were negative. Ocular lesions resolved after 13 weeks of treatment. Brain metastases developed after 20 weeks and were treated with radiation. Bilateral vitreous seeds recurred at 44 weeks and were treated with intravitreal chemotherapy (melphalan 20 μg/0.02 mL and topotecan 20 μg/0.02 mL). There was no extra-ocular spread from sclerotomy sites. Results: Retinoblastoma and brain metastases resolved with multimodal treatment without recurrence at 59 weeks of follow-up. Conclusion: Atypical manifestation of retinoblastoma can be seen in older children presenting with “floaters” and bilateral deposits of sub-ILM seeds, without solid tumor.
机译：目的：在一个11岁儿童中报告双侧视网膜母细胞瘤，其具有漂浮物和亚内部限制膜（亚ILM）种子。方法：一名11岁的孩子举办了4个月持续时间的漂浮物。检查揭示了两只眼性质的副作用区域中的含有周围的，发白，亚眠，絮状性结节。没有看到实体肿瘤。扫描源光学相干断层扫描揭示了子ILM空间中的中度反射回波。副ILM沉积物和细胞病理学检查的玻璃体吸入显示出视网膜母细胞瘤。玻璃体内脲烷（20μg/ 0.02ml）随后是6个月的高剂量全身化疗（长春甙，依托泊苷，卡铂）的每月循环。 RB1突变筛查的转移性余处和遗传检测是阴性的。在治疗13周后，眼病变已经解决。脑转移20周后开发，并用辐射治疗。双侧玻璃体在44周重复，并用玻璃体化疗（Melphalan20μg/ 0.02mL和Topotecan20μg/ 0.02mL）治疗。 Sclerotomy遗址没有额外的眼镜。结果：视网膜母细胞瘤和脑转移在59周的随访中没有复发。结论：用“漂浮物”和亚ILM种子的“漂浮物”和双侧沉积物的老年儿童可以看出视网膜母细胞瘤的非典型表现，没有实体瘤。

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