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首页> 外文期刊>Ocular oncology and pathology. >Atypical Retinal Pigment Epithelial Hyperplasia and Glial Proliferation Masquerading as Progressive Recurrent Retinoblastoma: A Case Report Review and Clinicopathologic Correlation
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Atypical Retinal Pigment Epithelial Hyperplasia and Glial Proliferation Masquerading as Progressive Recurrent Retinoblastoma: A Case Report Review and Clinicopathologic Correlation

机译：非典型视网膜色素上皮增生和胶合增殖伪装成渐进式复发性视网膜母细胞瘤：案例报告审查和临床病理学相关性

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摘要

Background: Recurrences of retinoblastoma tumors, particularly scar recurrences, are a common phenomenon in the management of this cancer. Consolidative treatment with laser and cryotherapy are required for local control of disease. It is known that consolidative therapy can induce retinal pigment epithelium (RPE) hyperplasia and gliosis. Herein we report extensive RPE hyperplasia and gliosis during laser therapy for a focal scar recurrence, which presented as a progressive retinal opacification mimicking active retinoblastoma. Method: This is a retrospective case review. Results: A 2-month-old premature male was diagnosed with sporadic bilateral retinoblastoma (International Intraocular Retinoblastoma Classification [IIRC] group B in the right eye and IIRC group A in the left eye). The patient underwent laser therapy for a focal recurrence which demonstrated a white lesion during therapy and was subsequently enucleated. While there was a focal recurrence and infiltration of the retina (seen both on optical coherence tomography and histopathologic section), the majority of the white, progressive lesion was from extensive RPE hyperplasia and gliosis secondary to laser therapy. Conclusion: Clinicopathologic correlation of the active recurrence and adjacent gliosis is demonstrated.
机译：背景：视网膜母细胞瘤肿瘤的复发，特别是瘢痕复发，是这种癌症管理中的常见现象。局部控制需要激光和冷冻疗法的合并治疗。众所周知，共同疗法可以诱导视网膜色素上皮（RPE）增生和胶质症。在此，我们在激光治疗期间报告广泛的RPE增生和神经病变，用于局灶性瘢痕复发，其作为模仿活性视网膜母细胞瘤的渐进式视网膜渗透率。方法：这是回顾性案例审查。结果：2个月大的早产均被诊断出孢子双侧视网膜母细胞瘤（右眼右眼和IIRC组A组B组B组B组）。患者接受激光治疗的局灶性复发，其在治疗过程中显示出白色病变，随后被引发。虽然视网膜的局灶性复发和浸润（在光学相干断层扫描和组织病理学部分观察），但大多数白色，渐进病变来自广泛的RPE增生和激光治疗中的胶质症。结论：证明了活性复发和相邻脊髓源的临床病理相关性。

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