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首页> 外文期刊>Ocular oncology and pathology. >Early and Late Histological and Ultrastructural Findings in Resected Infantile Capillary Hemangiomas Following Treatment with Topical Beta-Blocker Timolol Maleate 0.5%
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Early and Late Histological and Ultrastructural Findings in Resected Infantile Capillary Hemangiomas Following Treatment with Topical Beta-Blocker Timolol Maleate 0.5%

机译：早期和晚期组织学和超微结构发现，在局部β-阻滞剂氏炎马来酚的治疗后切除婴儿毛细血管血管瘤中的0.5％

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摘要

Background: Infantile capillary hemangiomas (IHs) affect approximately 4-5% of infants. The systemic nonselective beta-adrenergic antagonist, propranolol, has become the standard first-line treatment for severe IHs. The topical P-antagonist, timolol maleate, has also demonstrated efficacy and safety in treating superficial and some deep capillary hemangiomas. Despite their therapeutic success and prevalent use, the mechanism of action of 3-adrenergic antagonists in the treatment of IHs is not well understood. Methods: Histopathological and electron microscopic evaluation of two periocular IHs excised at 1 week and 24 months following topical timolol treatment was performed. Results: Distinct morphological differences were observed between spontaneously regressed and 3-antagonist-treated IHs. The former was characterized by diffuse collagen deposition and interstitial fibrosis, while the latter showed organized concentric collagen IV deposition within obliterated vessel lumen, suggestive of waves of endothelial cell apoptosis, leaving behind layers of basement membrane deposits as a stress response. Conclusions: Based on these observations, we hypothesize that, apart from their well-known cardiac and vasodilatory effects, 3-antagonists could induce endothelial cell apoptosis in IH leading to endovascular occlusion and we present supporting evidence to explain why this response might be specific to hypoxic tissue.
机译：背景：婴儿毛细血管血管瘤（IHS）影响约4-5％的婴儿。全身选择性β-肾上腺素能拮抗剂，普萘洛尔已成为严重IHS的标准第一线治疗。局部p-拮抗剂，蒂莫尔马来酸还表明了治疗浅表和一些深毛细血管瘤的疗效和安全性。尽管其治疗性成功和普遍存算，但3-肾上腺素能拮抗剂治疗IHS的作用机制并不顺利。方法：在局部纯摩尔治疗后1周和24个月内切除两种外观IHS的组织病理学和电子显微镜评价。结果：在自发回归和3-拮抗剂处理的IHS之间观察到不同的形态差异。前者的特征在于弥漫性胶原沉积和间质纤维化，而后者在湮灭血管内部显示有组织的同心胶原IV沉积，提出内皮细胞凋亡的波浪，留下基底膜沉积物层作为应力反应。结论：根据这些观察，我们假设，除了他们众所周知的心脏和血管舒张效应之外，3-拮抗剂可以诱导IH内皮细胞凋亡，导致血管内闭塞，我们提供支持证据来解释为什么这种反应可能具体缺氧组织。

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