Tumour Expression of Histone Deacetylases in Uveal Melanoma

Louis Levinzon; Michele Madigan; Vuong Nguyen; Enisa Hasic; Max Conway; Svetlana Cherepanoff

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Tumour Expression of Histone Deacetylases in Uveal Melanoma

机译：肿瘤脱乙酰酶在无过敏心肌瘤中的表达

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Purpose: To determine the expression of histone deacetylase enzymes in uveal melanoma tumour cells. Procedures: This is an observational immunohistochemical study of 16 formalin-fixed, paraffin-embedded eyes enucleated for uveal melanoma between January 2001 and March 2002. Haematoxylin and eosin paraffin sections were reviewed for histopathological parameters according to the American Joint Committee on Cancer 7th edition. Sections were then immunohistochemically stained for histone deacetylases 1, 2, 3, 4 and 6 and sirtuin 2 using an automated Leica Bond II platform and Fast Red chromogen, then digitally scanned using Aperio software before assessment of staining. Results: Nuclear expression of histone deacetylases 1, 2, 3, 4 and 6 and of sirtuin 2 was confirmed in uveal melanoma tumour cells. In addition, the tumour cells showed cytoplasmic expression of histone deacetylases 4 and 6 and sirtuin 2. Nuclear and cytoplasmic immunostaining was also seen in intraocular tissues uninvolved by the tumour. Conclusion: Uveal melanoma tumour cells express histone deacetylases 1, 2, 3, 4 and 6 and sirtuin 2, confirming potential tissue targets for histone deacetylase inhibitors.

机译：目的：确定UVEAL黑色素瘤肿瘤细胞中组蛋白脱乙酰酶酶的表达。程序：这是一种观察免疫组化学研究，对16件福尔马林固定的石蜡包埋的眼睛，在2001年1月至2002年3月至2002年3月至2002年3月至3月。据美国联合委员会第7版委员会审查了血红素蛋白和曙红石蜡切片。然后，使用自动LeaCa键II平台和快速红发色剂，在组蛋白脱乙酰酶1,2,3,4和6和Sirtuin 2中免疫染色部分，然后使用Aperio软件在评估染色之前进行数字扫描。结果：在Uveal Selanoma肿瘤细胞中证实了组蛋白脱乙酰酶1,2,3,4和6和Sirtuin 2的核表达。此外，肿瘤细胞显示组蛋白脱乙酰酶的细胞质表达4和6，Sirtuin22。在通过肿瘤未在肿瘤未植入的眼内组织中也看到核和细胞质免疫染色。结论：Uveal黑色素瘤肿瘤细胞表达组蛋白脱乙酰酶1,2,3,4和6和Sirtuin 2，确认组蛋白脱乙酰酶抑制剂的潜在组织靶标。

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《Ocular oncology and pathology.》 |2019年第3期|共9页
作者
Louis Levinzon; Michele Madigan; Vuong Nguyen; Enisa Hasic; Max Conway; Svetlana Cherepanoff;
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作者单位

Save Site Institute Sydney Medical School The University of Sydney Sydney Eye Hospital Sydney;

Save Site Institute Sydney Medical School The University of Sydney Sydney Eye Hospital Sydney;

Save Site Institute Sydney Medical School The University of Sydney Sydney Eye Hospital Sydney;

Save Site Institute Sydney Medical School The University of Sydney Sydney Eye Hospital Sydney;

Save Site Institute Sydney Medical School The University of Sydney Sydney Eye Hospital Sydney;

Save Site Institute Sydney Medical School The University of Sydney Sydney Eye Hospital Sydney;

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原文格式 PDF
正文语种 eng
中图分类眼肿瘤;
关键词
Uveal melanoma; Histone deacetylases; Sirtuins; Immunohistochemistry;

机译：Uveal黑色素瘤;组蛋白脱乙酰酶;SIRTUINS;免疫组化;

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专利

1. Tumour Expression of Histone Deacetylases in Uveal Melanoma [J] . Louis Levinzon, Michele Madigan, Vuong Nguyen, Ocular oncology and pathology. . 2019,第3期

机译：肿瘤脱乙酰酶在无过敏心肌瘤中的表达
2. Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines [J] . Susanna Nencetti, Doretta Cuffaro, Elisa Nuti, Journal of enzyme inhibition and medicinal chemistry. . 2021,第1期

机译：用（亚亚胺）氨基氧基支架活性在UVEAL Melanoma细胞系中的组蛋白脱乙酰酶抑制剂的鉴定
3. The Role of Histone Deacetylase Inhibitors in Uveal Melanoma: Current Evidence [J] . Moschos Marilita M., Dettoraki Maria, Androudi Sofia, Anticancer Research: International Journal of Cancer Research and Treatment . 2018,第7期

机译：组蛋白脱乙酰酶抑制剂在UVEAL黑色素瘤中的作用：当前证据
4. Manufacture and Clinical Results Using Tumour Infiltrating Lymphocytes for Metastatic Cutaneous, Uveal and Mucosal Melanoma in the UK [C] . John S. Bridgeman, Ryan Guest, Natalia Kirillova, PEGS . 2015

机译：在英国使用肿瘤浸润淋巴细胞的制造和临床结果，英国在英国中的转移皮肤，防御性和粘膜黑素瘤
5. Expression of histone deacetylase enzymes in murine and chick optic nerve. [D] . Tiwari, Sarika. 2013

机译：组蛋白脱乙酰基酶在鼠和小鸡视神经中的表达。
6. Tumour Expression of Histone Deacetylases in Uveal Melanoma [O] . Louis Levinzon, Michele Madigan, Vuong Nguyen, 2019

机译：葡萄膜黑色素瘤中组蛋白脱乙酰基酶的肿瘤表达
7. Identification of histone deacetylase inhibitors with (arylidene)aminoxy scaffold active in uveal melanoma cell lines [O] . Susanna Nencetti, Doretta Cuffaro, Elisa Nuti, 2020

机译：用（亚亚胺）氨基氧基支架活性在UVEAL Melanoma细胞系中的组蛋白脱乙酰酶抑制剂的鉴定

Tumour Expression of Histone Deacetylases in Uveal Melanoma

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