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首页> 外文期刊>Ocular oncology and pathology. >The Significance of Extracellular Cholesterol Crystals or a Cholesterol Granuloma in Xanthelasma
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The Significance of Extracellular Cholesterol Crystals or a Cholesterol Granuloma in Xanthelasma

机译：细胞外胆固醇晶体或铜酸粒粒细胞粒细胞粒细胞的意义

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Background/Aims: Xanthelasma is an unreliable indicator of systemic hyperlipidemia. A review in search of unusual histopathologic features of cellular composition that might correlate with systemic hyperlipidemia was conducted. Methods: An observational case series of 3 cases was performed. Slides were stained and analyzed with hematoxylin and eosin, Masson trichrome, and periodic acid-Schiff as well as for iron. Three lesions displayed an atypical morphologic finding and were subjected to immunohistochemical analysis for CD3, CD20, CD68, CD163, S100, and adipophilin. Results: The three lesions comprised in this study had classical xanthoma cells with densely packed fine vacuoles. The xanthoma cells were CD68, CD163, and adipophilin positive and S100 negative. In case 1, extracellular, nonpolarizing cholesterol crystalloids displayed totally negative staining for all biomarkers. In cases 2 and 3, the cholesterol granulomas were surrounded and permeated by CD68- or CD163-positive epithelioid and giant cells and by CD3-positive T lymphocytes. The 3 cases each harbored squamous cysts. Conclusion: In case 1, the uninflamed extracellular cholesterol crystalloids were associated with severely dysregulated systemic hyperlipidemia. In cases 2 and 3, the cholesterol granulomas were interpreted as a local manifestation of a cyst that might have partially ruptured and did not portend serious hyperlipidemia.
机译：背景/目标：Xanthelasma是一个不可靠的全身高脂血症指标。对可能与全身高脂血症进行相关的细胞组合物的异常组织病理学特征的审查进行了综述。方法：进行3例观察案例系列。用苏木精和曙红，Masson三相和周期性酸 - 席夫以及铁染色并分析载玻片。三个病变显示出非典型形态学发现，并对CD3，CD20，CD68，CD163，S100和脂肪素进行免疫组化分析。结果：本研究中包含的三种病变具有典型的Xanthoma细胞，具有密集的细液泡。 Xanthoma细胞是CD68，CD163和脂肪蛋白阳性和S100阴性。在壳体1中，细胞外，非极化胆固醇晶体对于所有生物标志物显示出完全负染色。在2和3例中，通过CD68或CD163阳性上皮细胞和CD3阳性T淋巴细胞包围和渗透胆固醇肉芽肿。 3例每个斑纹鳞状囊肿。结论：在案例1中，毫无束缚的细胞外胆固醇晶体与严重失调的全身高脂血症有关。在2和3例中，胆固醇肉芽肿被解释为可能部分破裂的囊肿的局部表现，并且没有移植严重的高脂血症。

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