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首页> 外文期刊>Ocular oncology and pathology. >BAP1 Immunoreactivity Correlates with Gene Expression Class in Uveal Melanoma
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BAP1 Immunoreactivity Correlates with Gene Expression Class in Uveal Melanoma

机译：BAP1免疫反应性与UVEAL黑色素瘤的基因表达类相关

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Background: Uveal melanoma (UM) is the most common intraocular tumour in adults. Currently there are different tests available to determine the risk of UM for metastasis, among which include BRCA1-associated protein-1 (BAP1) immunohistochemistry (IHC) and gene expression profiling (GEP). BAP1 is a deubiquitylating enzyme (DUB) that has tumour suppressor activity, the loss of which therefore is associated with higher risk for tumour growth and metastasis. Objectives: To compare and correlate the prognostic significance of BAP1-IHC staining patterns and GEP in the prediction of UM’s risk for metastasis. Methods: This is a retrospective chart review with prospective follow-up of patients with primary UM who underwent enucleation from the year 2008 to 2018. Clinical history, histopathologic findings, GEP classification, BAP1-IHC of the formalin-fixed paraffin-embedded tissues, and follow-up data for metastasis were collected and statistically analysed. Results: A total of 30 enucleated eyes with UM were included in the study. All class 1a tumours had high nuclear BAP1 expression and all class 2 had low nuclear BAP1 expression. Fifty percent of the class 1b tumours had low nuclear BAP1 expression. Among the tumours with low nuclear BAP1 expression, 68% developed metastasis, while 9% developed metastasis among high nuclear expression. Fifty-five percent developed metastasis in tumours with high cytoplasmic expression and 42% for low cytoplasmic expression. Predictive values for metastasis (positive predictive value, negative predictive value) are as follows: (1) nuclear BAP1-IHC (68%, 91%), (2) cytoplasmic BAP1-IHC (55%, 58%), and (3) GEP (73%, 80%). Nuclear BAP1-IHC and GEP had the same accuracy rate of 77% and cytoplasmic BAP1-IHC had an accuracy of 57%. Conclusion: Low nuclear BAP1-IHC strongly correlates with GEP class 2 and was equally accurate in the prediction of metastasis.
机译：背景：Uveal黑色素瘤（UM）是成人中最常见的眼内肿瘤。目前有不同的测试可用于确定转移的风险，其中包括BRCA1相关蛋白-1（BAP1）免疫组织化学（IHC）和基因表达分析（GEP）。 BAP1是具有肿瘤抑制活性的脱脂酶（DUB），因此损失与肿瘤生长和转移的风险较高。目的：要比较和关联Bap1-IHC染色模式和GEP在预测UM的转移风险中的预后意义。方法：这是一项回顾性的图表审查，该审查综述，患有2008年至2018年的初级UM患者的预期随访。临床历史，组织病理学发现，GEP分类，福尔马林固定石蜡包埋组织的BAP1-IHC，收集和统计分析转移的后续数据。结果：研究中共有30个肌肉眼睛。所有阶级1A肿瘤都具有高核BAP1表达，所有2类具有低核BAP1表达。 50％的1B级肿瘤具有低核BAP1表达。在低核BAP1表达的肿瘤中，68％发育的转移，而9％发育了高核表达中的转移。患有高细胞质表达高的肿瘤的五十五个百分之二的转移，42％用于低细胞质表达。转移的预测值（阳性预测值，阴性预测值）如下：（1）核BAP1-IHC（68％，91％），（2）细胞质BAP1-IHC（55％，58％）和（3 ）GEP（73％，80％）。核BAP1-IHC和GEP具有相同的精度率为77％，细胞质BAP1-IHC的精度为57％。结论：低核BAP1-IHC与GEP类2强烈相关，同样准确在转移的预测中。

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