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首页> 外文期刊>Ocular oncology and pathology. >Aggressive Ciliary Body Adenocarcinoma with Bilateral Lung Metastases: Histological, Molecular, Genetic and Clinical Aspects
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Aggressive Ciliary Body Adenocarcinoma with Bilateral Lung Metastases: Histological, Molecular, Genetic and Clinical Aspects

机译：具有双侧肺转移的侵袭性睫状体腺癌：组织学，分子，遗传和临床方面

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摘要

Purpose of the Study: To describe the clinical and histopathological features of an aggressive ciliary body adenocarcinoma with pulmonary metastases and skull base spread. Procedures and Results: A 45-year-old female patient presented with a post-traumatic phthisical eye that was eviscerated. This showed an unexpected carcinoma (positive for cytokeratins and melanocytic markers), the histological differential diagnosis for which included a primary ciliary body adenocarcinoma or a metastasis. The patient developed rapid post-surgical localized recurrence that required an orbital exenteration. This showed identical tumour to the evisceration specimen, with vascular invasion in orbital blood vessels and a contaminated orbital soft tissue margin. Staging imaging revealed multiple lung metastases, which were biopsied and shown to be a disseminated ciliary body adenocarcinoma rather than a disseminated primary lung carcinoma. The tumour spread locally to the skull base for which radiotherapy was given. Unfortunately, the patient passed away a few weeks later. Conclusions: To our knowledge, this is the first case of ciliary body adenocarcinoma with bilateral lung metastases. The malignant potential of these tumours should be considered as a possibility, and appropriate screening and staging tests should therefore be considered to guide appropriate management.
机译：该研究的目的：描述具有肺转移和颅底扩散的侵袭性睫状体腺癌的临床和组织病理学特征。程序和结果：一名45岁的女性患者呈现出展示后创伤后的耳聋眼睛。这显示出意想不到的癌（对细胞角蛋白和黑素细胞标志物阳性），其组织学鉴别诊断包括初级睫状体腺癌或转移。患者开发出快速的手术后局部复发，需要眶下出门。这表现出斑块标本相同的肿瘤，眶血管血管血管和污染的轨道软组织边距。分期成像显示多种肺转移，这是活检的，并且被证明是播散的睫状体腺癌而不是甲基原发性肺癌。肿瘤在局部分散到颅底，用于给出放射疗法。不幸的是，患者几个星期后逝世了。结论：据我们所知，这是第一种具有双侧肺转移的睫状体腺癌的案例。这些肿瘤的恶性潜力应被视为可能性，因此应考虑适当的筛选和分期测试来指导适当的管理。

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