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首页> 外文期刊>Ocular oncology and pathology. >No Gender Differences in Long-Term Survival after Brachytherapy of 1,541 Patients with Uveal Melanoma
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No Gender Differences in Long-Term Survival after Brachytherapy of 1,541 Patients with Uveal Melanoma

机译：近距离无过马英瘤患者的近距离放射治疗后长期存活的性别差异

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Background: In several malignancies, gender-based survival differences after specific therapeutic interventions have been demonstrated. It is not known whether such differences exist after plaque brachytherapy of uveal melanoma. Methods: All patients who received brachytherapy for uveal melanoma at St. Erik Eye Hospital from November 1, 1979 through November 20, 2017 were included ( n = 1,541). Retrospective data were retrieved including baseline patient and tumor characteristics, brachytherapy nuclide (ruthenium-106 or iodine-125), radiation dose, treatment duration, tumor relapses, date of metastasis, and cause of death. Results: A total of 775 men and 766 women were treated with plaque brachytherapy. There were no significant differences between the genders in baseline characteristics, treatment, or follow-up. Men and women had similar rates of tumor relapses, hazard for repeated brachytherapy (men vs. women 0.8, p = 0.47), enucleation-free survival, and survival after detection of metastasis. Five-, 10-, and 15-year melanoma-related mortality was 14, 24, and 27% for men and 15, 26, and 32% for women, respectively. There were no significant differences in hazard for melanoma-related mortality (men vs. women 0.9, p = 0.32), median Kaplan-Meier disease-specific survival (men 18.2 years, women 15.5 years, p = 0.22), or median overall survival (men 13.5 years, women 12.6 years, p = 0.60). Conclusion: There are no relevant differences between men and women in ocular or patient survival after brachytherapy for uveal melanoma.
机译：背景：在几种恶性肿瘤中，已经证明了特定治疗干预后的基于性别的生存差异。尚不清楚这种差异是否存在于Uveal黑色素瘤的斑块近距离放射治疗后。方法：从1979年11月1日至2017年11月20日到1979年11月20日至1979年11月20日，所有接受过寒云母瘤的所有患者接受过Uveal Selanoma的患者（n = 1,541）。检索回顾性数据，包括基线患者和肿瘤特征，近距离放射治疗核素（钌-106或碘-125），辐射剂量，治疗持续时间，肿瘤复发，转移日期和死亡原因。结果：共有775名男性和766名女性用斑块近距离放射治疗治疗。基线特征，治疗或随访之间的性别之间没有显着差异。男女患有类似的肿瘤率复发，反复近距离放射治疗的危害（男性与妇女0.8，P = 0.47），在转移检测后的无核生存和存活。对于女性的男性和15,26,26,26,26,26,26,26,26,26,26,26,26,26,26,26,22％，5-24,24％和32％。对黑色素瘤相关死亡率的危害没有显着差异（男性与女性0.9，P = 0.32），中位Kaplan-Meier病疾病生存（男性18.2岁，女性15.5岁，P = 0.22），或中位整体生存（男子13.5岁，女性12.6岁，P = 0.60）。结论：近距离黑素瘤的近距离放射治疗后眼部或患者存活中没有相关差异。

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