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Diversity of the oral microbiome between dentate and edentulous individuals

机译：牙齿和薄弱个体之间的口腔微生物组的多样性

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摘要

Abstract Background Measurement of saliva microbes is promoted as a way to detect oral and systemic disease, yet there is a multitude of factors that affect the oral microbiome. The salivary microbiome is influenced by oral biofilm of shedding (epithelial) and non‐shedding (tooth) surfaces. Methods To gauge the ability of salivary microbial analytics to distinguish between edentulous and dentate oral conditions, we looked for differences in the saliva microbiome of subjects with and without teeth. Fifty‐two dentate and 49 edentulous subjects provided stimulated saliva samples. 16S rRNA gene sequencing, QIIME‐based data processing, and statistical analysis were done using several different analytical approaches to detect differences in the salivary microbiome between the two groups. Results Bacteria diversity was lower in the edentulous group. Remarkably, all 31 of the most significant differences in taxa were deficits that occur in the edentulous group. As one might expect many of these taxa are attributed to dental plaque and gingival sulcus associated bacteria. Conclusion In sum, the measurement of 16S rRNA genes in the bacteria of the saliva can be used to reproducibly measure differences in the oral microbiome that occur with edentulism, mainly the lack of tooth and tooth‐related structures.
机译：摘要唾液微生物的背景测量促进了检测口腔和全身疾病的一种方式，但存在影响口腔微生物组的多种因素。唾液微生物组受脱落（上皮）和非脱落（牙齿）表面的口服生物膜的影响。衡量唾液微生物分析能力区分术术和牙齿的口腔条件的方法，我们寻找有和没有牙齿的受试者的唾液微生物组的差异。五十二个牙齿和49个未伪造的受试者提供刺激的唾液样品。 16S RRNA基因测序，使用几种不同的分析方法进行基于血管基的数据处理和统计分析，以检测两组之间唾液微生物组的差异。结果细菌多样性在薄弱组中较低。值得注意的是，出现的所有31种分类群差异都是透明组出现的赤字。由于人们可能期望许多这些分类群归因于牙菌斑和牙龈相关细菌。结论总和，唾液细菌中16S rRNA基因的测量可用于可重复地测量依法性发生的口腔微生物组的差异，主要是缺乏牙齿和牙齿相关的结构。

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  • 来源
    《Oral diseases》 |2019年第3期|共8页
  • 作者

    Gazdeck R. Kyle; Fruscione Sarah R.; Adami Guy R.; Zhou Yalu; Cooper Lyndon F.; Schwartz Joel L.;

  • 作者单位

    Department of Prosthodontics and Implant InnovationUniversity of Illinois at ChicagoChicago Illinois;

    Department of Oral Medicine and Diagnostic Sciences College of DentistryUniversity of Illinois at;

    Department of Oral Medicine and Diagnostic Sciences College of DentistryUniversity of Illinois at;

    Department of Oral Medicine and Diagnostic Sciences College of DentistryUniversity of Illinois at;

    Department of Oral Biology College of DentistryUniversity of Illinois at ChicagoChicago Illinois;

    Department of Oral Medicine and Diagnostic Sciences College of DentistryUniversity of Illinois at;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 口腔科学;
  • 关键词

    dentate; edentulous; microbiome; periodontal pathogens; saliva;

    机译：牙齿;伪心;微生物组;牙周病原体;唾液;

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