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Cariogenic microbiome and microbiota of the early primary dentition: A contemporary overview

机译：致龋微生物和早期牙本质的微生物瘤：当代概述

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Abstract Recent advances in the field of molecular microbiology provide an unprecedented opportunity to decipher the vast diversity of the oral microbiome in health and disease. Here, we provide a contemporary overview of the oral microbiome and the microbiota of early childhood caries (ECC) with particular reference to newer analytical techniques. A MEDLINE search revealed a total of 20 metagenomic studies describing cariogenic microbiomes of ECC, 10 of which also detailed the healthy microbiomes. In addition, seven studies on site‐specific microbiomes, focusing on acidogenic and aciduric microbiota of deep‐dentinal lesions, were also reviewed. These studies evaluated plaque and saliva of children aged 1.5–11?years, in cohorts of 12–485 individuals. These studies reveal a very rich and diverse microbial communities, with hundreds of different phylotypes and microbial species, including novel species and phyla such as Scardovia wiggsiae, Slackia exigua, Granulicatella elegans, Firmicutes in the plaque biofilms of children with ECC. On the contrary, bacteria such as Streptococcus cristatus, S.?gordonii, S.?sanguinis, Corynebacterium matruchotii, and Neisseria flavescens were common in plaque biofilm of noncarious, healthy, tooth surfaces in subjects with caries. The review illustrates the immense complexity and the diversity of the human oral microbiota of the cariogenic plaque microbiome in ECC, and the daunting prospect of its demystification.
机译：摘要分子微生物学领域的最新进展提供了一个前所未有的机会，可以破译健康和疾病中的口腔微生物组的大量多样性。在这里，我们提供了一种当代概述了口腔微生物组和早期儿童龋病（ECC）的微生物群，特别是更新的分析技术。 MEDLINE搜索揭示了20项MECAGOMIC研究，描述了ECC的致癌微生物，其中10个也详细描述了健康的微生物体。此外，还综述了七种特异性微生物的研究，重点介绍深牙本病变的酸性微生物群。这些研究评估了1.5-11岁的儿童的斑块和唾液，在12-485人的群组中。这些研究揭示了一种非常丰富和多样化的微生物社区，其中数百种不同的种植和微生物物种，包括新颖的物种和植物，如赤列症状Wiggsiae，Slackia Exigua，Granulicatella elegans，在患有ECC的儿童斑块生物膜的牙菌质中的核心。相反，细菌如链球菌，S.？戈登尼，S.？anguinis，棒状基因杆菌和Neisseria flavescens在龋齿的斑块生物膜斑块生物膜中是常见的。审查说明了ECC中致癌斑块微生物组的巨大复杂性和人口腔微生物群的多样性，以及其恶化的令人生畏的前景。

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