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Association of TLR2, TLR3, TLR4 and CD14 genes polymorphisms with oral cancer risk and survival

机译：TLR2，TLR3，TLR4和CD14基因多态性与口腔癌症风险和生存的关联

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摘要

Objectives: The aim of this study is to investigate association between polymorphisms in TLR2, TLR3, TLR4 and CD14 genes or their haplotypes with oral squamous cell carcinomas (OSCC) risk and survival. Methods: The study was conducted on 93 OSCC patients and 104 cancer-free controls. Polymorphisms were genotyped by real-time PCR or PCR-RFLP method. Results: Significant increase in oral cancer risk was observed in individuals with mutated genotype of TLR3 rs3775291 polymorphism (OR = 1.096, P = 0.036) compared to wild-type. The heterozygous and mutated genotype of TLR3 rs5743312 polymorphism had worse survival in group of patients with stage III tumours (P = 0.043). Multivariate Cox regression analysis revealed that TLR3 rs5743312 polymorphism could be considered as prognostic marker in advanced III stage OSCC (HR = 2.456, P = 0.007), but not independently of nodal status. TLR3 rs3775291 and rs5743312 polymorphisms were in strong linkage disequilibrium. Haplotype TG was associated with worse prognosis in OSCC patients in comparison with common CG haplotype (HR = 1.717, P = 0.042). Interaction among polymorphisms in TLR2, TLR3 and CD14 genes was observed (P = 0.010). Conclusions: TLR3 rs5743312 polymorphism could be considered as potential predictor of worse overall survival in advanced oral cancer, but not independently of nodal status. Haplotypes in TLR3 gene might be associated with poor prognosis in OSCC patients.
机译：目的：本研究的目的是调查TLR2，TLR3，TLR4和CD14基因或其具有口腔鳞状细胞癌（OSCC）风险和存活的单倍型之间的多态性之间的关联。方法：该研究是在93例OSCC患者和104例无癌症对照中进行的。通过实时PCR或PCR-RFLP方法基因分型多态性。结果：与野生型相比，在具有TLR3 RS3775291多态性（或= 1.096，P = 0.036）的个体中观察到口腔癌风险的显着增加。 TLR3 rs5743312多态性的杂合和突变基因型在III期患者组中的存活率差（P = 0.043）。多变量Cox回归分析显示，TLR3 RS5743312多态性可以被认为是在高级III阶段OSCC（HR = 2.456，P = 0.007）中的预后标志物，但不能独立于节点状态。 TLR3 RS3775291和RS5743312多态性在强烈的联系不平衡中。单倍型TG与OSCC患者的预后与常见的CG单倍型（HR = 1.717，P = 0.042）相比有关。观察到TLR2，TLR3和CD14基因多态性之间的相互作用（P = 0.010）。结论：TLR3 RS5743312多态性可被认为是晚期口腔癌的总体生存率更严重的潜在预测因子，但不能独立于节点状态。 TLR3基因中的单倍型可能与OSCC患者的预后不良有关。

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  • 来源
    《Oral diseases》 |2014年第4期|共9页
  • 作者

    ZeljicK.; SupicG.; JovicN.; KozomaraR.; Brankovic-MagicM.; ObrenovicM.; MagicZ.;

  • 作者单位

    Institute for Medical Research Military Medical Academy Belgrade Serbia Faculty of Biology;

    Institute for Medical Research Military Medical Academy Belgrade Serbia Faculty of Medicine;

    Faculty of Medicine Military Medical Academy University of Defence Belgrade Serbia Clinic for;

    Faculty of Medicine Military Medical Academy University of Defence Belgrade Serbia Clinic for;

    Institute for Oncology and Radiology Belgrade Serbia;

    Faculty of Medicine University of East Sarajevo Foca Bosnia and Herzegovina;

    Institute for Medical Research Military Medical Academy Belgrade Serbia Faculty of Medicine;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 口腔科学;
  • 关键词

    CD14; Haplotypes; Oral cancer risk; Overall survival; Single-nucleotide polymorphisms; TLR;

    机译：CD14;单倍型;口腔癌症风险;整体存活;单核苷酸多态性;TLR;

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