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首页> 外文期刊>Oral diseases >Depth of invasion on pathological outcomes in clinical low‐stage oral tongue cancer patients
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Depth of invasion on pathological outcomes in clinical low‐stage oral tongue cancer patients

机译：临床低级口腔舌癌患者病理结果的侵袭深度

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摘要

Abstract Objectives Depth of invasion was added to the eighth edition American Joint Committee on Cancer guidelines for T staging of HPV ‐negative oral cavity squamous cell carcinoma. Our aim was to determine the impact of depth of invasion on pathological variables and outcomes in low‐stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. Subjects and Methods All clinical T1/T2 N0 HPV ‐negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included. Logistic regression models and Cox proportional hazard models were used to examine pathological variables, recurrence, and 3‐year disease‐free survival. Results Sixty‐seven patients met criteria; the mean age was 52.0 ( SD : 17.7). Depth of invasion was a significant predictor of occult metastasis ( OR : 2.0, p ?=?0.05) and lymphovascular invasion ( OR : 4.1, p ?=?0.02), and tumor thickness was a significant predictor of lymphovascular invasion ( OR : 3.3, p ?=?0.04). None of the variables were predictive of recurrence or disease‐free survival. Conclusion Depth of invasion at biopsy may be a potential useful metric to inform on regional management selection in this radiographic node‐negative population.
机译：摘要侵犯了南京癌症癌症准则第八届癌症指南委员会的景深。我们的目标是确定入侵深度对低级舌癌患者病理变量和结果的影响。我们还研究了肿瘤厚度和肿瘤临床分期对比较的影响。受试者和方法所有临床T1 / T2 N0 HPV - 在2000年至2015年间在我们的机构接受了在我们的机构之间接受选修颈部解剖的癌症患者。 Logistic回归模型和Cox比例危险模型用于检查病理变量，复发和3年无病生存率。结果六十七名患者达到标准;平均年龄为52.0（SD：17.7）。侵袭的深度是神经转移的重要预测因子（或：2.0，p？0.05）和淋巴血管侵袭（或：4.1，p？0.02），肿瘤厚度是淋巴血管侵袭的显着预测因子（或：3.3 ，p？= 0.04）。没有变量是预测复发或无疾病的存活率。结论活检侵袭的深度可能是一个潜在的可用度量，以通知区域管理选择在该放射线节点阴性人群中。

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  • 来源
    《Oral diseases》 |2018年第7期|共6页
  • 作者

    Masood Maheer M.; Farquhar Douglas R.; Vanleer Jessica P.; Patel Samip N.; Hackman Trevor G.;

  • 作者单位

    Department of Otolaryngology/Head and Neck SurgeryUniversity of North Carolina at Chapel Hill;

    Department of Otolaryngology/Head and Neck SurgeryUniversity of North Carolina at Chapel Hill;

    Department of Pathology and Laboratory MedicineUniversity of North Carolina at Chapel Hill School;

    Department of Otolaryngology/Head and Neck SurgeryUniversity of North Carolina at Chapel Hill;

    Department of Otolaryngology/Head and Neck SurgeryUniversity of North Carolina at Chapel Hill;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 口腔科学;
  • 关键词

    cancer and precancer; oncology; otorhinolaryngology;

    机译：癌症和癌症;肿瘤学;Otorhinolaryngology;

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