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首页> 外文期刊>Oral diseases >Role of oral examination in newly diagnosed multiple myeloma patients: A safe and simple way to detect light chain amyloidosis
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Role of oral examination in newly diagnosed multiple myeloma patients: A safe and simple way to detect light chain amyloidosis

机译：口腔检查在新诊断的多发性骨髓瘤患者中的作用：一种安全而简单的方法来检测轻链淀粉样症状

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摘要

Abstract Objective Up to 30% of multiple myeloma ( MM ) patients have subclinical amyloid deposits. These patients are under‐recognized and are more susceptible to drug toxicity, bleeding and death. Early diagnosis and adjustment of treatment are crucial. Biopsies of oral mucosa might be a potentially useful diagnostic tool. The objective of this study was to assess the prevalence and characteristics at presentation of oral amyloidosis in a large cohort of MM patients. Methods The prevalence and characteristics of oral amyloidosis in a large cohort of MM patients who were referred for oral evaluation before and during bisphosphonate therapy were assessed, retrospectively. Results Among 212 patients analysed, 13 (6%) were diagnosed with concomitant light chain ( AL ) amyloidosis. In 54% ( n? = ? 7), lesions in the oral cavity compatible with amyloid deposition were detected by examination. Conclusions The salient feature of this study is the high prevalence of oral manifestations among MM patients with amyloidosis. These results highlight the value of routine oral cavity examination and biopsy as a safe and simple method for detecting light chain amyloidosis.
机译：摘要目的高达30％的多发性骨髓瘤（mm）患者具有亚临床淀粉样沉积物。这些患者经受公认的，更容易受到药物毒性，出血和死亡的影响。治疗的早期诊断和调整至关重要。口腔粘膜的活组织检查可能是一个潜在有用的诊断工具。本研究的目的是评估大群MM患者口服淀粉样蛋白病的患病率和特征。方法回顾性地评估在双膦酸盐治疗前和双膦酸盐治疗前后评估的大群患者口腔淀粉样蛋白病的患病率和特征进行评估。结果212名患者分析，13例（6％）被诊断为伴随的轻链（Al）淀粉样蛋白病。在54％（n？=β7）中，通过检查检测与淀粉样蛋白沉积相容的口腔中的病变。结论本研究的突出特征是MM蛋黄过病患者口服表现的高患病率。这些结果突出了常规口腔检查和活检的价值作为检测轻链淀粉样蛋白病的安全和简单方法。

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  • 来源
    《Oral diseases》 |2018年第7期|共6页
  • 作者

    Leiba Merav; Jarjoura Suha; Abboud Waseem; Nagler Arnon; Yahalom Ran; Duek Adrian; Yarom Noam;

  • 作者单位

    Division of HematologyBen Gurion University of the NegevBeersheba Israel;

    Department of Otolaryngology Head and Neck Surgery and Maxillofacial SurgeryTel Aviv Sourasky;

    Department of Oral and Maxillofacial SurgerySheba Medical CenterTel Hashomer Israel;

    Division of Hematology and Bone Marrow TransplantationSheba Medical CenterTel Hashomer Israel;

    Department of Oral and Maxillofacial SurgerySheba Medical CenterTel Hashomer Israel;

    Division of Hematology and Bone Marrow TransplantationSheba Medical CenterTel Hashomer Israel;

    Oral Medicine UnitSheba Medical CenterTel Hashomer Israel;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 口腔科学;
  • 关键词

    amyloidosis; multiple myeloma; oral manifestation;

    机译：淀粉样蛋白化;多发性骨髓瘤;口语表现;

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