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Sugars and beyond. The role of sugars and the other nutrients and their potential impact on caries

机译:糖和超越。 糖和其他营养素的作用及其对龋齿的潜在影响

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摘要

The traditional concept of caries as a multifactorial transmittable and infectious disease has been challenged. Novel conceptual ideas have come to add to the complexity of this highly prevalent disease worldwide. Current etiological understanding of the disease has emphasized the pivotal role of sugars in caries. In fact, current definition points toward an ecological disease caused by the commensal microbiota that under ecological imbalances, mainly due to high and or frequent sugars consumption, creates a state of dysbiosis in the dental biofilm. This modern conceptual idea, however, tends to underrate a key issue. As humans are omnivore and consume a mix diet composed by a multitude of substances, the role of the diet in caries must not be restricted only to the presence of fermentable sugars. This review explores the contribution of other food components, ubiquitous to the diet, mostly as potentially protective factors. Anticaries nutrients might determine an environmental change, affecting the ecology of the oral microbiome and partially mitigating the effect of sugars. Understanding the function of the food usually consumed by the people will contribute new knowledge on the mechanisms associated with the onset of caries, on new caries risk variables and on potential novel strategies for the prevention and treatment of the disease.
机译:传统的龋齿概念作为多学习可传播和传染病的挑战。新颖的概念思想已经增加到全球这种高度普遍的疾病的复杂性。目前对疾病的病因理解强调了糖在龋齿中的关键作用。事实上,目前的定义指向由共生微生物群引起的生态疾病,这在生态失衡下,主要是由于糖消耗的高和或频繁,牙科生物膜中的消化不良状态。然而,这种现代概念思想往往会估计一个关键问题。由于人类是难犯,并且消耗由多种物质组成的混合饮食,饮食在龋齿中的作用不得仅限于可发酵糖的存在。本综述探讨了其他食物组分,普遍存在饮食的贡献,主要是潜在的保护区因子。侵略性营养素可能会确定环境变化,影响口腔微生物组的生态,部分减轻糖的作用。了解人们通常消费的食物的功能将为新的龋病风险变量和预防和治疗疾病的潜在新策略提供关于与龋齿发作相关的机制的新知识。

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