Utility of MS-MLPA in DNA methylation profiling in primary laryngeal squamous cell carcinoma.

Fernando López; Teresa Sampedro; José L Llorente; Francisco Domínguez; Mario Hermsen; Carlos Suárez; César Alvarez-Marcos

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Utility of MS-MLPA in DNA methylation profiling in primary laryngeal squamous cell carcinoma.

机译：原发性喉鳞状细胞癌DNA甲基化分析中MS-MLPA的效用。

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Promoter methylation profiling of LSCC using MS-MLPA identified CDKN2B, DAPK1, RARβ, APC, and CHFR as frequent epigenetic events. The clinical implications of these genes as biomarkers are highly relevant as attractive targets for cancer therapy, given the reversible nature of epigenetic gene silencing.

机译：使用MS-MLPA鉴定的CDKN2B，DAPK1，RARβ，APC和CHFR作为频繁的表观遗传事件的LSCC的启动子甲基化分析。鉴于表观遗传基因沉默的可逆性，这些基因作为生物标志物作为生物标志物的临床意义是对癌症治疗的吸引力靶标。

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《Oral oncology》 |2014年第4期|共7页
作者
Fernando López; Teresa Sampedro; José L Llorente; Francisco Domínguez; Mario Hermsen; Carlos Suárez; César Alvarez-Marcos;
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Department of Otorhinolaryngology and Instituto Universitario de Oncología del Principado de;

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正文语种 eng
中图分类耳鼻咽喉科学;
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专利

1. Utility of MS-MLPA in DNA methylation profiling in primary laryngeal squamous cell carcinoma. [J] . Fernando López, Teresa Sampedro, José L Llorente, Oral oncology . 2014,第4期

机译：MS-MLPA在原发性喉鳞状细胞癌DNA甲基化分析中的效用。
2. Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum [J] . FurlanD., SahnaneN., MazzoniM., Virchows Archiv: an international journal of pathology . 2013,第1期

机译：MS-MLPA在结肠直肠癌和神经内分泌癌DNA甲基化分析中的诊断作用
3. Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon–rectum [J] . Daniela Furlan, Nora Sahnane, Mara Mazzoni, Virchows Archiv . 2013,第1期

机译：MS-MLPA在结肠直肠癌和神经内分泌癌DNA甲基化分析中的诊断作用
4. Genes associated with genotype-specific DNA methylation in squamous cell carcinoma as candidate drug targets [C] . Ryoichi Kinoshita, Mitsuo Iwadate, Hideaki Umeyama, Asia-Pacific Bioinformatics Conference . 2014

机译：与鳞状细胞癌中基因型特异性DNA甲基化相关的基因作为候选药物靶标
5. Methylation in head and neck squamous cell carcinoma. [D] . Bennett, Kristi L. 2007

机译：头颈部鳞状细胞癌中的甲基化。
6. DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [O] . Goot Heah Khor, Gabriele Ruth Anisah Froemming, Rosnah Binti Zain, 1989

机译：DNA甲基化分析揭示原发性口腔鳞状细胞癌中启动子过度甲基化诱导的p16，DDAH2和DUSP1沉默。
7. DNA Methylation Profiling Revealed Promoter Hypermethylation-induced Silencing of p16, DDAH2 and DUSP1 in Primary Oral Squamous Cell Carcinoma [O] . Khor G. H., Froemming G. R. A., Zain R. B., 2014

机译：DNA甲基化分析揭示原发性口腔鳞状细胞癌中启动子过度甲基化诱导的p16，DDAH2和DUSP1沉默。

Utility of MS-MLPA in DNA methylation profiling in primary laryngeal squamous cell carcinoma.

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