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首页> 外文期刊>Osteoarthritis and cartilage >Long-term effect of removal of knee joint loading on cartilage quality evaluated by delayed gadolinium-enhanced magnetic resonance imaging of cartilage
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Long-term effect of removal of knee joint loading on cartilage quality evaluated by delayed gadolinium-enhanced magnetic resonance imaging of cartilage

机译：通过延迟钆增强的软骨延迟钆增强磁共振成像评估软骨质量的长期效果

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Objective: Ankle fracture patients were used as a model to study the long-term effect of the removal of joint loading on knee cartilage quality in human subjects. Design: The knees of 10 patients with ipsilateral ankle fractures were investigated using delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) at the time of ankle injury. After 6 weeks' prescribed unloading of the affected leg, but no restrictions regarding knee movement, the cast was removed from the ankle and the patient underwent a second dGEMRIC examination. Physiotherapy was then initiated. A third dGEMRIC examination was performed 4 months after remobilization, and a final examination 1 year after the injury. Results: Baseline T1Gd values for the 10 patients were within a narrow range. No significant change in mean T1Gd was observed after 6 weeks' prescribed unloading, but the T1Gd range had increased significantly. Four months after remobilization, the mean T1Gd was significantly lower than in the previous examinations, and the range remained significantly broader than at baseline. At the 1-year follow-up, the mean T1Gd was almost identical to the value after remobilization, and the T1Gd range still showed a significant increase compared to the baseline investigation. Conclusions: Removal of knee cartilage loading for 6 weeks resulted in a measurable effect on the cartilage matrix, as evidenced by a broader T1Gd range. A decrease in mean T1Gd was observed 4 months after remobilization. These differences persisted a year after injury compared to baseline.
机译：目的：踝关节骨折患者用作研究人类受试者膝关节软骨质量去除的长期效果的模型。设计：在踝关节损伤时使用延迟的钆增强磁共振成像（Dgemric）的延迟钆增强磁共振成像来研究10例同侧踝骨骨折的膝关节。经过6周的规定卸下受影响的腿，但没有关于膝关节运动的限制，从踝关节中除去铸件，患者经历了第二次DGEMIC检查。然后启动物理疗法。在重新化后4个月进行第三次DgEmric检查，损伤后1年的最终检查。结果：10名患者的基线T1GD值在狭窄范围内。 6周规定卸载后，未观察到平均T1GD的显着变化，但T1GD范围显着增加。重新化四个月后，平均T1GD显着低于先前的检查，并且该范围仍然明显比基线更广泛。在1年的随访中，平均T1GD几乎与重组后的值几乎相同，与基线调查相比，T1GD范围仍然显着增加。结论：去除膝关节软骨载荷6周，导致软骨基质的可测量效果，如更广泛的T1GD范围所证明的。复发后4个月观察到平均T1GD的降低。与基线相比，这些差异持续了一年。

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