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Osteoarthritis year in review 2017: biology

机译：骨关节炎年度评论2017年：生物学

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This Year in Review was derived from a personal selection of articles investigating biological mechanisms of osteoarthritis (OA) and presented at the OARSI World Congress on April 30, 2017. Selected articles were published between the March, 2016 and April, 2017 OARSI meetings. PubMed/MEDLINE searches were performed using the terms "osteoarthritis", "cartilage", "subchondral bone", "synovium", "synovitis", and "ageing". Biomechanical, genetic, genomic, epigenomic, biomarker, clinical, imaging, and tissue engineering studies were excluded since they are covered by other articles in this series. Several new and emerging themes were identified. Incorporating new technologies such as designer genetic engineering, nanotechnology, and bio-selective nuclear medicine tracers into study designs helps to gain important insights into OA pathophysiology. Potentially critical differences exist between biological mechanisms of post-traumatic, age-associated, and metabolic phenotypes of OA. The concept of OA stages is highlighted, demonstrating how this may influence which biological mechanisms are at play and the need for strategic timing of treatment interventions. Not all inflammation is bad and fine-tuning a balance within inflammatory signaling mechanisms may be a path to regain joint homeostasis. Not only is the joint an organ system, sub-regions within each joint tissue, especially the joint lining, may play distinct roles in damage and repair. To accompany the review, the interaction among studies spanning multiple areas is summarized schematically. (C) 2017 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
机译：今年的审查是来自个人选择的各种文章，调查了骨关节炎（OA）的生物机制，并于2017年4月30日在Oarsi世界大会上提交。选定的文章于2016年3月和2017年4月，2017年3月oarsi会议上发表。使用“骨关节炎”，“软骨”，“Subchondral骨”，“Symovium”，“滑膜炎”和“老化”进行了PubMed / Medline搜索。由于本系列中的其他文章覆盖，因此排除了生物力学，遗传，基因组，表观胶质，生物标志，临床，成像和组织工程研究。确定了一些新的和新兴的主题。纳入设计师基因工程，纳米技术和生物选择性核医学示踪剂等新技术，进入研究设计有助于获得对OA病理生理学的重要见解。生物后，年龄相关性和OA代谢表型的生物机制之间存在潜在的临界差异。突出显示OA阶段的概念，证明这可能会影响哪种生物机制在游戏中以及治疗干预措施的战略时机的需求。并非所有炎症都不糟糕，并且炎症信号传导机制内的平衡可能是重新获得联合稳态的道路。不仅有关器官系统，每个关节组织内的子区域，尤其是关节衬里，可能在损坏和修复方面发挥明显的作用。为了伴随审查，跨越多个区域的研究之间的相互作用示意性地概述了。 （c）2017年由elsevier有限公司发布代表骨关节炎研究协会国际国际。

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