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The role of macrophages in osteoarthritis and cartilage repair

机译：巨噬细胞在骨关节炎和软骨修复中的作用

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摘要

Osteoarthritis (OA) is a family of degenerative diseases affecting multiple joint tissues. Despite the diverse etiology and pathogenesis of OA, increasing evidence suggests that macrophages can play a significant role in modulating joint inflammation, and thus OA severity, via various secreted mediators. Recent advances in next-generation sequencing technologies coupled with proteomic and epigenetic tools have greatly facilitated research to elucidate the embryonic origin of macrophages in various tissues including joint synovium. Furthermore, scientists have now begun to appreciate that macrophage polarization can span beyond the conventionally recognized binary states (i.e., pro-inflammatory M1-like vs anti-inflammatory M2-like) and may encompass a broad spectrum of phenotypes. Although the presence of these cells has been shown in multiple joint tissues, additional mechanistic studies are required to provide a comprehensive understanding of the precise role of these diverse macrophage populations in OA onset and progression. New approaches that can modulate macrophages into desired functional phenotypes may provide novel therapeutic strategies for preventing OA or enhancing cartilage repair and regeneration. (C) 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
机译：骨关节炎（OA）是一种影响多个关节组织的退行性疾病家族。尽管OA的不同病因和发病机制，但越来越多的证据表明，巨噬细胞可以通过各种分泌的介质调节关节炎症，从而在调节关节炎症中发挥重要作用。与蛋白质组学和表观遗传工具相结合的下一代测序技术的最新进展具有很大程度上促进了研究，以阐明各种组织中巨噬细胞的胚胎起源。此外，科学家们现在已经开始理解，巨噬细胞极化可以超出常规识别的二元态（即，促炎M1样VS抗炎M2样），并且可以包含广谱的表型。虽然这些细胞的存在已经显示在多个关节组织中，但是需要额外的机械研究来提供对这些不同巨噬细胞群体在OA发作和进展中的确切作用的全面了解。可以调节巨噬细胞进入所需功能表型的新方法可以提供用于预防OA或增强软骨修复和再生的新的治疗策略。 （c）2020年骨关节炎研究协会国际。 elsevier有限公司出版。保留所有权利。

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