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首页> 外文期刊>Schweizer Archiv fur Tierheilkunde >Effect of tranexamic acid on intra- and postoperative haemorrhage in dogs with surgically treated hemoperitoneum
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Effect of tranexamic acid on intra- and postoperative haemorrhage in dogs with surgically treated hemoperitoneum

机译：Tranexamic酸对手术治疗血管基犬术后术后出血的影响

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摘要

Tranexamic acid (TXA) is an antifibrinolytic drug that is used for uncontrolled bleeding of various origin. This retrospective study investigated the effect of tranexamic acid administration on bleeding tendency in dogs with surgically managed hemoperitoneum. Thirty dogs were treated with (TXA group) and 25 dogs without (CTR group) tranexamic acid prior to surgery. Various parameters (decrease in haernatocrit, number of transfusions, shock index and changes in abdominal fluid accumulation) were used for characterization of bleeding tendency and compared between groups. Groups were similar at presentation and prior to surgery. None of the dogs undergoing rotational thromboelastography analysis showed hyperfibrinolysis prior to surgery. Overall transfusion and erythrocyte transfusion requirements as well as bleeding tendency, hospitalisation time and hospital discharge rate were similar between groups. Dogs of the TXA group received significantly more intraoperative plasma transfusions (P=0.013) and showed a higher systolic and mean arterial blood pressure (P=0.002 and 0.050) and lower shock index (P=0.028) with less dogs being in shock (P=0.012) at 24h. In summary, in this study population of dogs with surgically managed spontaneous hemoperitoneum dogs treated with tranexamic acid received more plasma transfusions intraoperatively and showed a lower shock index 24h after presentation. In dogs with surgically treated hemoabdomen tranexamic acid administration prior to surgery does not reduce red blood cell transfusion requirements or postoperative bleeding tendency.
机译：Tranexamic acid（TXA）是一种防纤维蛋白溶解剂，用于不受控制各种起源的出血。该回顾性研究研究了宁酸酸施用对手术管理血管基犬出血倾向的影响。在手术前，用（TXA组）和25只狗治疗了30只狗，没有（CTR群）Tranexamic酸。使用各种参数（减少左侧左右，输血次数，冲击指数和腹部流体积累的变化）用于表征出血倾向并在组之间进行比较。群体在呈现和手术之前类似。没有经历旋转血栓间隙分析的狗没有显示出在手术前的高纤维蛋白溶解。在组之间存在整体输血和红细胞输血要求以及出血趋势，住院时间和医院排放率相似。 TXA组的狗接受了更高的术中血浆输血（P = 0.013），并显示出更高的收缩性和平均动脉血压（P = 0.002和0.050），较少的休克指数（P = 0.028），较少的狗处于冲击（P = 0.012）在24小时。总之，在这项研究中，用促甲蛋白酸处理的手术管理自发血红蛋白犬的犬群接受了更多的血浆输血，在介绍后24h显示出较低的休克指数。在手术前用手术治疗的血管培育酸给药的狗没有减少红细胞输血要求或术后出血倾向。

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