...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>BJU international >The effect of obesity and lower serum prostate-specific antigen levels on prostate-cancer screening results in American men.
【24h】

The effect of obesity and lower serum prostate-specific antigen levels on prostate-cancer screening results in American men.

机译：肥胖和血清前列腺特异性抗原水平降低对美国男性前列腺癌筛查的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: To determine if lower serum total prostate specific antigen (PSA) levels in obese American men affect prostate-cancer screening results, as an increased body mass index (BMI) is inversely associated with PSA level, but the effect of this association on PSA screening results for prostate cancer is unknown. SUBJECTS AND METHODS: We analysed the most recent National Health and Nutrition Examination Surveys (NHANES 2001-2002, 2003-2004, and 2005-2006), a nationally representative cross-sectional sample of non-institutionalized adults aged > or =20 years. Logistic regression was used to estimate the odds of an 'abnormal' PSA level (4.0 or 2.5 ng/mL) based on BMI categories of normal (18.5-24.9 kg/m(2)), overweight (25-29.9) and obese (30-39.9) in men who were eligible for prostate-cancer screening with serum total PSA tests (age 40-75 years, BMI 18.5-39.9 kg/m(2), PSA <20 ng/mL). RESULTS: In all, 3152 participants with no known prostate cancer, representing 46 million American men, were eligible for prostate-cancer screening. After controlling for age and race, there was a statistically significant trend of a lower likelihood of having a serum total PSA level of > or =4.0 ng/mL with increased BMI. When men were stratified by race, this effect was apparent only in white non-Hispanic men, with obese men in this group having a 46% lower likelihood of having an 'abnormal' PSA level (odds ratio 0.54, 95% confidence interval 0.31-0.91; P = 0.024) than those with a normal BMI. There was no observable trend in either African-American or Hispanic men. In addition, there was no observable trend with a serum total PSA threshold of 2.5 ng/mL, regardless of race. CONCLUSIONS: Obese white non-Hispanic men are about half as likely as those with a normal BMI to have a PSA level of > or =4.0 ng/mL. These results might affect prostate-cancer screening with serum total PSA. Further studies are needed to better define the association of BMI and PSA in racial minority subgroups.
机译：目的：确定肥胖的美国男性中较低的血清总前列腺特异性抗原（PSA）水平是否会影响前列腺癌的筛查结果，因为体重指数（BMI）的升高与PSA水平成反比，但这种关联对PSA的影响前列腺癌的筛查结果未知。受试者和方法：我们分析了最新的国家健康和营养检查调查（NHANES 2001-2002、2003-2004和2005-2006），这是年龄大于或等于20岁的非机构化成年人的全国代表性横断面样本。基于正常（18.5-24.9 kg / m（2）），超重（25-29.9）和肥胖（BMI）的BMI类别，使用Logistic回归估计PSA“异常”水平（4.0或2.5 ng / mL）的几率。 30-39.9岁）的男性有资格接受血清PSA总血清测试（年龄40-75岁，BMI 18.5-39.9 kg / m（2），PSA <20 ng / mL）。结果：共有3152名没有已知前列腺癌的参与者（代表4,600万美国男性）符合前列腺癌筛查的条件。在控制了年龄和种族之后，存在统计学上显着的趋势，即随着BMI的增加，血清总PSA水平>或等于4.0 ng / mL的可能性降低。当男性按种族分层时，这种效果仅在非西班牙裔白人男性中明显，该组中的肥胖男性具有“异常” PSA水平的可能性降低46％（几率0.54，95％置信区间0.31） 0.91; P = 0.024）。非洲裔美国人或西班牙裔男子均无明显趋势。此外，无论种族如何，血清总PSA阈值为2.5 ng / mL均无明显趋势。结论：肥胖的非西班牙裔白人男性PSA水平≥4.0ng / mL的可能性约为正常BMI男性的一半。这些结果可能会影响血清总PSA对前列腺癌的筛查。需要进行进一步的研究以更好地定义少数民族少数群体中BMI和PSA的关联。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号