Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro

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Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro

机译：掩盖的三英癸烯和酸甲酮霉菌毒素可承受上胃肠道的消化和吸收，但在体外，人体肠道微生物有效地水解

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Scope: Cereal grains are commonly contaminated with Fusarium mycotoxins and their plant-derived masked metabolites. The fate of masked mycotoxins in the human gut is poorly understood. Here we assess the metabolism and transport of glucoside metabolites of common trichothecenes (deoxynivalenol, nivalenol, T-2 toxin) and zearalenone compounds (zearalenone, alpha-and beta-zearalenol) in the human gut in vitro.

机译：范围：谷物颗粒通常被镰刀菌霉菌毒素及其植物衍生的掩蔽代谢物污染。人肠道中蒙面霉菌毒素的命运很难理解。在这里，我们评估在体外人体肠道中常见的三胞菌（脱氧酚，Nivalenol，Nivalenol，T-2毒素，Zearalenone，α-和β-酸甲烯醇）的葡萄糖苷代谢物的代谢和运输。

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《Molecular Nutrition and Food Research》 |2017年第4期|共10页
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正文语种 eng
中图分类食品工业;
关键词
Caco-2; Deoxynivalenol; Glucoside; Hydrolysis; Nivalenol; HT-2 toxin;

机译：Caco-2;脱氧肾上腺素;葡萄糖苷;水解;Nigalenol;HT-2毒素;

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1. Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro [J] . Molecular Nutrition and Food Research . 2017,第4期

机译：掩盖的三英癸烯和酸甲酮霉菌毒素可承受上胃肠道的消化和吸收，但在体外，人体肠道微生物有效地水解
2. Biotransformation of the Mycotoxin Zearalenone to its Metabolites Hydrolyzed Zearalenone (HZEN) and Decarboxylated Hydrolyzed Zearalenone (DHZEN) Diminishes its Estrogenicity In Vitro and In Vivo [J] . Sebastian Fruhauf, Barbara Novak, Veronika Nagl, Toxins . 2019,第8期

机译：将霉菌毒素的生物转化霉菌与其代谢物水解的Zealalenone（HZEN）和脱羧水解的酸甲酮（DHZEN）在体外和体内减少其雌激素
3. Gastrointestinal digestion of food-use silver nanoparticles in the dynamic SIMulator of the GastroIntestinal tract (simgi (R)). Impact on human gut microbiota [J] . Cueva Carolina, Gil-Sanchez Irene, Tamargo Alba, Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2019,第期

机译：食品用食物用银纳米粒子的胃肠道消化在胃肠道的动态模拟器中（Simgi（R））。对人体肠道微生物的影响
4. CHELATED IRON SOURCES AS INHIBITORS OF PSEUDOMONAS AERUGINOSA BIOFILMS AND DISTRIBUTION EFFICIENT IN AN IN VITRO MODEL OF DRUG DELIVERY TO THE HUMAN LUNG [C] . Dinty J. Musk Jr., Paul J. Hergenrother American Chemical Society National Meeting . 2007

机译：螯合的铁源作为假单胞菌铜绿假单胞菌的抑制剂和分布在人肺的药物递送的体外模型中的分布
5. Interactions between Dietary Flavonoid Apigenin and Human Gut Microbiota in vitro [D] . Wang, Minqian. 2018

机译：膳食黄酮类化合物和人体肠道微生物体外的相互作用
6. Biotransformation of the Mycotoxin Zearalenone to its Metabolites Hydrolyzed Zearalenone (HZEN) and Decarboxylated Hydrolyzed Zearalenone (DHZEN) Diminishes its Estrogenicity In Vitro and In Vivo [O] . Sebastian Fruhauf, Barbara Novak, Veronika Nagl, 2019

机译：霉菌毒素玉米赤霉烯酮对其代谢产物水解玉米赤霉烯酮（HZEN）和脱羧水解玉米赤霉烯酮（DHZEN）的生物转化降低了其体内和体内的雌激素性。
7. Biotransformation of the Mycotoxin Zearalenone to its Metabolites Hydrolyzed Zearalenone (HZEN) and Decarboxylated Hydrolyzed Zearalenone (DHZEN) Diminishes its Estrogenicity In Vitro and In Vivo [O] . Sebastian Fruhauf, Barbara Novak, Veronika Nagl, 2019

机译：将霉菌毒素的生物转化霉菌与其代谢物水解的Zealalenone（HZEN）和脱羧水解的酸甲酮（DHZEN）在体外和体内减少其雌激素

Masked trichothecene and zearalenone mycotoxins withstand digestion and absorption in the upper GI tract but are efficiently hydrolyzed by human gut microbiota in vitro

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