Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis

Foreid Siri; Gadeholt Gaut

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Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis

机译：β-羟基丁酸酯和焦醛酸盐可包括在快速GC-MS筛选方法中，用于鉴别代谢酸中毒的鉴别诊断

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A rapid gas chromatographic mass spectrometric method for measuring anions associated with acute anion gap metabolic acidosis is described. The method is an extension of a previous method. The method quantifies glycolic acid, beta-hydroxybutyric acid with good linearity and pyroglutamic acid with a reproducible curvature relation between 1 and 20mmol/L and can help the clinician distinguish effectively between ethylene glycol poisoning, alcoholic and diabetic ketoacidosis and cysteine deficiency so early that it will have clinical consequences.

机译：描述了一种快速气相色谱质谱法，用于测量与急性阴离子间隙代谢酸中的阴离子的测量。该方法是先前方法的扩展。该方法用良好的线性度和焦化酸和焦化酸，烧焦酸β-羟基丁酸量化，在1到20mmol / L之间可再现的曲率关系，并且可以帮助临床医生有效地区分乙二醇中毒，酒精和糖尿病酮症病毒和半胱氨酸缺乏将有临床后果。

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《Scandinavian journal of clinical and laboratory investigation.》 |2017年第8期|共4页
作者
Foreid Siri; Gadeholt Gaut;
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作者单位

Oslo Univ Hosp Dept Pharmacol N-0424 Oslo Norway;

Oslo Univ Hosp Dept Pharmacol N-0424 Oslo Norway;

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原文格式 PDF
正文语种 eng
中图分类诊断学;
关键词
Analytical techniques; clinical pharmacology; clinical toxicology; gas chromatography; mass spectrometry;

机译：分析技术;临床药理学;临床毒理学;气相色谱;质谱;

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1. Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis [J] . Foreid Siri, Gadeholt Gaut Scandinavian journal of clinical and laboratory investigation. . 2017,第1a8期

机译：β-羟基丁酸酯和焦醛酸盐可包括在快速GC-MS筛选方法中，用于鉴别代谢酸中毒的鉴别诊断
2. Differential diagnosis of nongap metabolic acidosis: Value of a systematic approach [J] . KrautJ.A., MadiasN.E. Clinical journal of the American Society of Nephrology: CJASN . 2012,第4期

机译：非空洞性代谢性酸中毒的鉴别诊断：系统方法的价值
3. Differential Diagnosis of Nongap Metabolic Acidosis: Value of a Systematic Approach [J] . Jeffrey A. Kraut, Nicolaos E. Madias Clinical journal of the American Society of Nephrology: CJASN . 2012,第4期

机译：Nongap代谢性酸中毒的鉴别诊断：系统方法的价值
4. A Rapid LC-hrMS Method for Metabolite Identification Simultaneously to Metabolic Stability Assessment on Microsomes at an Early Screening Stage [C] . Didier Bressac, Emmanuel Hardillier, Olivier Lacombe International Mass Spectrometry Conference . 2014

机译：一种快速LC-HRMS方法，用于代谢物鉴定对早期筛查阶段微粒体的代谢稳定性评估
5. Investigation of Pathogenicity, Competitive Fitness, and Novel Methods for Rapid Diagnosis of Salmonella 4,[5],12:i:- in Swine [D] . Naberhaus, Samantha Ann. 2019

机译：调查致病性，竞争性健康和新型方法，用于快速诊断沙门氏菌4，[5]，12：I： - 在猪
6. Final diagnosis of 86 cases included in differential diagnosis ofAmerican tegumentary leishmaniasis in a Brazilian sample: a retrospectivecross-sectional study [O] . Fernanda Tirelli, Sebastian Vernal, Ana Maria Roselino 2017

机译：最终诊断为86例其中包括巴西样品中的美国皮膜性利什曼病：回顾性研究横断面研究
7. Aim: To investigate the value of ElastPQ measurement for differential diagnosis of benign and malignant focal liver lesions (FLLs) by using histologic results as a reference standard. Material and methods: A total of 154 patients were included. ElastPQ measurement was performed for each lesion in which the shear wave speed (SWS) was measured. The difference in SWS and SWS ratio of FLL to surrounding liver were evaluated, and the cut off value was investigated. Receiver operating characteristic (ROC) curve was plotted to evaluate the diagnostic performance. Histology as a gold standard was obtained by surgery in all patients. Results: A total of 154 lesions including 129 (83.7 ) malignant FLLs and 25 (16.3 ) benign ones were analysed. The SWS of malignant and benign FLLs was significantly different, 2.77±0.68 m/s and 1.57±0.55 m/s (p<0.05). The SWS ratio of each FLL to surrounding liver parenchyma was 2.23±0.49 for malignant and 1.14±0.36 for benign FLLs (p<0.05). The cut off value for differential diagnosis was 2.06 m/s for SWS and 1.67 for SWS ratio. Conclusions: ElastPQ measurement provides reliable quantitative stiffness information of FLLs and may be helpful in the differential diagnosis between malignant and benign FLLs. [O] . Yi Dong, Wen-Ping Wang, Yadan Xu, 2017

机译：目的：通过使用组织学结果作为参考标准，研究ELASTPQ测量对良性和恶性局灶性肝病变（FLLS）的鉴别诊断的价值。材料和方法：共有154名患者。对测量剪切波速度（SWS）的每个病变进行ELASTPQ测量。评估了FL1与周围肝脏的SWS和SWS比的差异，研究了切断值。接收器操作特征（ROC）曲线被绘制以评估诊断性能。组织学作为金标准通过患者的手术获得。结果：共有154例病变，包括129名（83.7％）恶性FLLS和25（16.3％）良性物质。 SWS的恶性和良性FLLS显着差异，2.77±0.68 m / s和1.57±0.55 m / s（p <0.05）。对于良性FLL的恶性为2.23±0.36，每个FL1与周围肝实质的SWS比为2.23±0.36（P <0.05）。差分诊断的切断值为SWS和SWS比率为2.06米/秒。结论：ELASTPQ测量提供了FLLS的可靠定量刚度信息，可能有助于恶性和良性FLL之间的差异诊断。
8. METHODS FOR RAPID GRAPHICAL EVALUATION OF COOLED OR UNCOOLED TURBOJET AND TURBOPROP ENGINE OR COMPONENT PERFORMANCE (EFFECTS OF VARIABLE SPECIFIC HEAT INCLUDED) [R] . Jack B. Esgar, Robert R. Ziemer 1955

机译：冷却或冷却涡轮和湍流发动机或部件性能的快速图形评估方法（包括可变比热的影响）

Beta-hydroxybutyrate and pyroglutamate can be included in a rapid GC-MS screening method for differential diagnosis of metabolic acidosis

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