...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Scandinavian journal of medicine & science in sports. >Osteoarthritis biomarker responses and cartilage adaptation to exercise: A review of animal and human models
【24h】

Osteoarthritis biomarker responses and cartilage adaptation to exercise: A review of animal and human models

机译：骨关节炎生物标志物反应和软骨适应行使：对动物和人类模型的综述

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Regular physical activity has been suggested as having both preventive and therapeutic benefits for individuals with osteoarthritis (OA). However, evidence of whether exercise and which type of exercise constitutes a benefit or a risk in the development and progression of OA remains debatable. This may be due to the evaluation of the effect of physical activity or new disease‐modifying OA drugs which is currently based on radiographic criteria (eg, joint space width) and the lack of correlation with clinical signs and symptoms (eg, pain and loss of function). Moreover, OA typically manifests itself as changes within the joint space and subchondral bone as well as the whole joint structure, including progressive degradation of cartilage, menisci, ligaments, and synovial inflammation. Biomarkers are being developed to quantify joint remodeling and disease progression notably involving the articular cartilage and synovial fluid. The primary purpose of this review was to evaluate the current literature and to provide further insight based on OA biomarkers and the role physical activity plays in the management of OA. Osteoarthritis biomarkers together with radiographic imaging evidence will ideally guide healthcare providers to incorporate exercise recommendations into clinical management and offer patients evidence‐based and individually tailored exercise prescriptions.
机译：已经提出了定期的身体活动，因为对骨关节炎（OA）的个体具有预防和治疗益处。但是，举行练习的证据以及哪种运动的效益或风险仍然是值得简言的。这可能是由于评估目前基于射线照相标准（例如，关节空间宽度）和与临床症状和症状缺乏相关性的物理活性或新的疾病修饰的OA药物（例如，疼痛和损失的相关性功能）。此外，OA通常表现为联合空间和子骨髓内骨内的变化以及整个关节结构，包括软骨，肿瘤，韧带和滑膜炎症的逐渐降解。正在开发生物标志物以定量显着涉及关节软骨和滑膜液的关节重塑和疾病进展。本综述的主要目的是评估当前的文献，并根据OA生物标志物提供进一步的洞察力，并在OA管理中扮演体力活动。骨关节炎生物标志物与放射线影像学成像证据一起将理想地指导医疗保健提供者将行使建议纳入临床管理，并提供患者的证据和单独量身定制的运动处方。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号