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首页> 外文期刊>Scandinavian journal of medicine & science in sports. >Skeletal muscle IL IL ‐15/ IL IL ‐15Rα and myofibrillar protein synthesis after resistance exercise
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Skeletal muscle IL IL ‐15/ IL IL ‐15Rα and myofibrillar protein synthesis after resistance exercise

机译：骨骼肌IL IL -15 / IL IL-15Rα和肌原纤维蛋白合成抗性运动后

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摘要

In vitro and in vivo studies described the myokine IL ‐15 and its receptor IL ‐15Rα as anabolic/anti‐atrophy agents, however, the protein expression of IL ‐15Rα has not been measured in human skeletal muscle and data regarding IL ‐15 expression remain inconclusive. The purpose of the study was to determine serum and skeletal muscle IL ‐15 and IL ‐15Rα responses to resistance exercise session and to analyze their association with myofibrillar protein synthesis ( MPS ). Fourteen participants performed a bilateral leg resistance exercise composed of four sets of leg press and four sets of knee extension at 75% 1 RM to task failure. Muscle biopsies were obtained at rest, 0, 4 and 24?hours post‐exercise and blood samples at rest, mid‐exercise, 0, 0.3, 1, 2, 4 and 24?hours post‐exercise. Serum IL ‐15 was increased by ~5.3‐fold immediately post‐exercise, while serum IL ‐15Rα decreased ~75% over 1?hour post‐exercise ( P .001). Skeletal muscle IL ‐15Rα mRNA and protein expression were increased at 4?hours post‐exercise by ~2‐fold ( P .001) and ~1.3‐fold above rest ( P =.020), respectively. At 24?hours post‐exercise, IL ‐15 ( P =.003) and IL ‐15Rα mRNA s increased by ~2‐fold ( P =.002). Myofibrillar fractional synthetic rate between 0‐4?hours was associated with IL ‐15Rα mRNA at rest ( r =.662, P =.019), 4?hours ( r =.612, P =.029), and 24?hours post‐exercise ( r =.627, P =.029). Finally, the muscle IL ‐15Rα protein up‐regulation was related to Leg press 1 RM ( r =.688, P =.003) and total weight lifted ( r =.628, P =.009). In conclusion, IL ‐15/ IL ‐15Rα signaling pathway is activated in skeletal muscle in response to a session of resistance exercise.
机译：体外和体内研究描述了Myokine IL -15及其受体IL-15Rα作为代谢/抗萎缩剂，然而，IL-15Rα的蛋白表达尚未在人骨骼肌和关于IL -15表达的数据中测量保持不确定。该研究的目的是测定血清和骨骼肌IL -15和IL-15Rα对抵抗运动会议的反应，并分析它们与Myofibrillar蛋白质合成（MPS）的关联。十四名参与者进行了双侧腿部阻力运动，由四组腿部压力机组成，4套膝盖延伸，以75％1 RM为任务故障。肌肉活组织检查在休息，0,4和24小时获得，休息后运动和血液样本，中间运动，0,0.3,1,2,4和24小时的运动后锻炼，0,0,0.3,1,2,4小时。血清IL -15后立即增加〜5.3倍，而血清IL-15Rα在运动后1〜2小时内降低〜75％（P <.001）。骨骼肌IL-15RαmRNA和蛋白质表达分别在运动后4〜2倍（p＆ .001）和〜1.3倍以上的〜1.3倍（p = .020）。在运动后24小时，IL -15（P = .003）和IL-15RαmRNAS增加〜2倍（P = .002）。 0-4小时之间的Myofibrarrar分数合成率与IL-15RαmRNA静止（R = .662，p = .019），4个？小时（r = .612，p = .029）和24小时练习后（r = .627，p = .029）。最后，肌肉IL-15Rα蛋白质上调与腿部压力有关（r = .688，p = .003）和总重量（r = .628，p = .009）。总之，IL -15 / IL-15Rα信号通路在骨骼肌中响应于抵抗运动的会话而激活。

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