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首页> 外文期刊>Sensor Letters: A Journal Dedicated to all Aspects of Sensors in Science, Engineering, and Medicine >Molecularly Imprinted Polymer Sensor Based on Microporous Metal-Organic Framework for Detection of Doxorubicin Hydrochloride
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Molecularly Imprinted Polymer Sensor Based on Microporous Metal-Organic Framework for Detection of Doxorubicin Hydrochloride

机译:基于微孔金属 - 有机框架的分子印迹聚合物传感器检测多柔明素盐酸盐素

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摘要

Doxorubicin Hydrochloride is an antineoplastic which is widely used. At present, a sensitive electrochemical molecularly imprinted sensor was developed to detect Doxorubicin Hydrochloride based on a gold electrode modified with p-aminothiophenol (PATP) functionalized gold nanoparticles (AuNPs) in the presence of Doxorubicin Hydrochloride as template molecule. After the extraction of the template molecules, the holes which can identify and combine with Doxorubicin Hydrochloride with high efficiency are formed directly. The performance of the developed sensor was characterized by Square Wave Voltammetry using hexacyanoferrate/hexacyanoferrite ([Fe(CN)_6]~(-3/-4)) as redox probe. The sensor with a signal-to-noise ratio of 3 exhibits a generalized linearity between 1.72 nM to 1.72 μM and a detection limit of 0.067 nM which is relatively lower than the other methods. Compared to non-imprinted sensor without binding template molecules, the imprinted sensor reveals high selectivity and good reproducibility. Furthermore, the developed sensor was successfully applied to test the levels of Doxorubicin hydrochloride in spiked serum samples.
机译:盐酸辛酸多柔比星是一种广泛使用的抗肿瘤塑料。目前,开发了一种敏感的电化学分子印迹传感器以基于用p-氨基酚(Patp)官能化的金纳米粒子(AUNP)在盐酸莫霉素作为模板分子的情况下进行改性的金电极来检测多柔比霉素盐酸盐。在提取模板分子之后,直接形成可以鉴定和与多柔比星盐酸盐合并具有高效率的孔。开发的传感器的性能以方形波伏安法使用六氰基甲酸酯/己酰基甲醛([Fe(CN)_6]〜(-3 / -4))作为氧化还原探针。具有3的信噪比的传感器具有1.72nm至1.72μm的广义线性,检测限为0.067nm,其比其他方法相对低。与不具有结合模板分子的非印记传感器相比,压印传感器显示出高选择性和良好的再现性。此外,已成功地应用发育传感器以测试尖刺血清样品中的多柔比星蛋白水平。

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