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首页> 外文期刊>Seminars in cell and developmental biology >Planarian regeneration between 1960s and 1990s: From skilful baffled ancestors to bold integrative descendants. A personal account
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Planarian regeneration between 1960s and 1990s: From skilful baffled ancestors to bold integrative descendants. A personal account

机译：20世纪60年代和九十世纪90年代之间的平面图再生：从湛蓝的祖先到大胆的综合后代。 个人账户

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摘要

Scientific fields grow by accretion of knowledge brought up by succesive generations of scientists. With the field of planarian regeneration as a general background, here I give a personal account of it from the late 1960s until the late 1990s when new research groups, namely Americans, broke into it. After a short historical summary, I report how I got into regeneration, why I choose planarians, and most especially the finding and description of the current model organism Schmidtea mediterranea. Next, I concentrate on the quantitative cellular approaches to regeneration, growth, and degrowth undertaken in our lab in Barcelona, and the long struggle to set neoblasts as a totipotent/pluripotent heterogeneous population of mitotic and non-mitotic cells for homeostatic somatic cell renewal, reproduction, and blastema formation during regeneration. Finally, the first attempts by several labs to analyze regeneration in molecular terms (RNAs, proteins, mAbs, gene detection, cloning and expression) are also covered.
机译：由成功几代科学家所带来的知识增强的科学领域增长。随着平面图再生的领域作为一般背景，在这里，我从20世纪60年代后期到20世纪90年代末，当新的研究群体，即美国人，闯入它时，我从20世纪60年代末举行了个人账户。经过短暂的历史摘要，我报告了我如何进入再生，为什么我选择平面军，以及最尤其是当前模型生物的发现和描述Schmidtea Mediterranea。接下来，我专注于在巴塞罗那实验室中进行的定量细胞方法，以便在巴塞罗那的实验室中进行，以及将新生儿的长期斗争作为稳态体细胞更新的全能/多能异细胞群，再生过程中的繁殖和Blastema形成。最后，还覆盖了几种实验室以分子术语（RNA，蛋白，MAb，基因检测，克隆和表达）分析再生的尝试。

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