...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Science Signaling >The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression
【24h】

The adaptor molecule RIAM integrates signaling events critical for integrin-mediated control of immune function and cancer progression

机译：适配器分子RIAM集成了对整合蛋白介导的免疫功能和癌症进展的关键关键的信令事件

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lymphocyte activation requires adhesion to antigen-presenting cells. This is a critical event linking innate and adaptive immunity. Lymphocyte adhesion is accomplished through LFA-1, which must be activated by a process referred to as inside-out integrin signaling. Among the few signaling molecules that have been implicated in inside-out integrin activation in hematopoietic cells are the small guanosine triphosphatase (GTPase) Rapl and its downstream effector Rapl-interacting molecule (RIAM), a multidomain protein that defined the MiglO-RIAM-lamellipodin (MRL) class of adaptor molecules. Through its various domains, RIAM is a critical node of signal integration for activation of T cells, recruits monomeric and polymerized actin to drive actin remodeling and cytoskeletal reorganization, and promotes inside-out integrin signaling in T cells. As a regulator of inside-out integrin activation, RIAM affects multiple functions of innate and adaptive immunity. The effects of RIAM on cytoskeletal reorganization and integrin activation have implications in cell migration and trafficking of cancer cells. We provide an overview of the structure and interactions of RIAM, and we discuss the implications of RIAM functions in innate and adaptive immunity and cancer.
机译：淋巴细胞活化需要粘附到抗原呈递细胞。这是链接先天和自适应免疫的关键事件。通过LFA-1完成淋巴细胞粘附，其必须通过称为内部整合蛋白信号传导的过程激活。在造血细胞中涉及内部整合蛋白激活的少数信号分子中是小鸟嘌呤三磷酸酶（GTP酶）Rapl及其下游效应Rapl-相互作用分子（RIAM），其多域蛋白质，其定义了MIGLO-RIAM-LAMELLIPODIN （MRL）适配器分子类别。通过其各个域，RIAM是用于激活T细胞的信号集成的关键节点，新募集单体和聚合的肌动蛋白，以驱动肌动蛋白的重塑和细胞骨骼重组，并促进T细胞中的内部整合蛋白信号传导。作为内部整合素激活的监管机构，Riam会影响先天和自适应免疫的多种功能。 RAM对细胞骨骼重组和整联素激活的影响对细胞迁移和贩运癌细胞的影响具有影响。我们概述了RIAM的结构和互动，我们讨论了RIAM功能在先天和自适应免疫和癌症中的影响。

著录项

  • 来源
    《Science Signaling》 |2017年第493期|共12页
  • 作者

    Nikolaos Patsoukis; Kankana Bardhan; Jessica D. Weaver; Duygu Sari; Alvaro Torres-Gomez; Lequn Li; Laura Strauss; Esther M. Lafuente; Vassiliki A. Boussiotis;

  • 作者单位

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

    Division of Hematology-Oncology Beth Israel Deaconess Medical Center Harvard Medical School Boston MA 02215 USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号