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首页> 外文期刊>Science Signaling >Palmitoylation of delta-catenin promotes kinesin-mediated membrane trafficking of Na(v)1.6 in sensory neurons to promote neuropathic pain
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Palmitoylation of delta-catenin promotes kinesin-mediated membrane trafficking of Na(v)1.6 in sensory neurons to promote neuropathic pain

机译：Delta-catenin的棕榈酰致促进Kinesin介导的膜流量在感觉神经元中的Na（v）1.6，以促进神经性疼痛

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摘要

Palmitoylation of delta-catenin is critical to synapse plasticity and memory formation. We found that delta-catenin palmitoylation is also instrumental in the development of neuropathic pain. The abundances of palmitoylated delta-catenin and the palmitoyl acyltransferase DHHC3 were increased in dorsal root ganglion (DRG) sensory neurons in rat models of neuropathic pain. Inhibiting palmitoyl acyltransferases or decreasing delta-catenin abundance in the DRG by intrathecal injection of 2-bromopalmitate or shRNA, respectively, alleviated oxaliplatin or nerve injury-induced neuropathic pain in the rats. The palmitoylation of delta-catenin, which was induced by the inflammatory cytokine TNF-alpha, facilitated its interaction with the voltage-gated sodium channel Na(v)1.6 and the kinesin motor protein KIF3A, which promoted the trafficking of Na(v)1.6 to the plasma membrane in DRG neurons and contributed to mechanical hypersensitivity and allodynia in rats. These findings suggest that a palmitoylation-mediated KIF3A/delta-catenin/Na(v)1.6 complex enhances the transmission of mechanical and nociceptive signals; thus, blocking this mechanism may be therapeutic in patients with neuropathic pain.
机译：Delta-catenin的棕榈酰基对突触可塑性和记忆形成至关重要。我们发现Delta-catenin palmitoylation也是在发育神经性疼痛的发展中的工具。棕榈酰基化δ-catenin和棕榈酰酰基转移酶DHHC3的丰度在神经病疼痛大鼠模型中的背根神经节（DRG）感官神经元中增加。通过鞘内注射2-溴透露或shRNA，抑制棕榈酰酰基转移酶或降低DRG中的Delta-Catenin丰度，缓解奥沙利铂或神经损伤诱导的大鼠神经性疼痛。由炎性细胞因子TNF-α诱导的Delta-catenin的棕榈酰基促进其与电压门控钠通道Na（v）1.6的相互作用，促进纳米（v）1.6的贩运在DRG神经元中的血浆膜，有助于大鼠的机械超敏反和异常性。这些发现表明，棕榈酰基介导的KIF3A / delta-catenin / Na（v）1.6复合物增强了机械和伤害性信号的透射;因此，阻断这种机制可以是神经性疼痛患者的治疗性。

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  • 来源
    《Science Signaling》 |2018年第523期|共13页
  • 作者

    Zhang Xiao-Long; Ding Huan-Huan; Xu Ting; Liu Meng; Ma Chao; Wu Shao-Ling; Wei Jia-You; Liu Cui-Cui; Zhang Su-Bo; Xin Wen-Jun;

  • 作者单位

    Sun Yat Sen Univ Affiliated Hosp 1 Zhongshan Sch Med Neurosci Program Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Zhongshan Sch Med Neurosci Program Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Zhongshan Sch Med Neurosci Program Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Zhongshan Sch Med Neurosci Program Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Rehabil Med Guangzhou 510120 Guangdong Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Rehabil Med Guangzhou 510120 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Zhongshan Sch Med Neurosci Program Guangzhou 510080 Guangdong Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Rehabil Med Guangzhou 510120 Guangdong Peoples R China;

    Sun Yat Sen Univ Sun Yat Sen Mem Hosp Dept Rehabil Med Guangzhou 510120 Guangdong Peoples R China;

    Sun Yat Sen Univ Affiliated Hosp 1 Zhongshan Sch Med Neurosci Program Guangzhou 510080 Guangdong Peoples R China;

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  • 正文语种 eng
  • 中图分类 细胞生物学;
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