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首页> 外文期刊>Sexual medicine reviews. >Neuroimaging of Female Sexual Desire and Hypoactive Sexual Desire Disorder
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Neuroimaging of Female Sexual Desire and Hypoactive Sexual Desire Disorder

机译：女性性欲望和低吸力性欲障碍的神经模仿

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Introduction: Recent advances in neuroimaging offer an unprecedented window into the female sexual brain. The small samples and poor statistical power of individual functional magnetic resonance imaging studies have limited what can be gleaned about the systematic brain network that is involved in female sexual desire and female sexual dysfunction (eg, hypoactive sexual desire disorder [HSDD]). Aim: To quantitatively determine the brain network involved in HSDD. Methods: Systematic retrospective review and statistical meta-analysis of pertinent neuroimaging literature. Main Outcome Measures: Review of published literature on functional magnetic resonance imaging studies illustrating brain regions associated with female sexual desire and female HSDD. Results: HSDD is associated with a specific fronto-limbic-parietal dysfunction characterized by (i) lower blood oxygen level-dependent responses in the sexual desire brain network and (ii) higher blood oxygen level-dependent responses in the self-referential brain network. Conclusion: The meta-analytic results are in line with a top-down neurofunctional model of HSDD in which inspecting, monitoring, and evaluating oneself (rather than sensory experience) before or during sexual activities interfere with sexual desire. These results raise new questions regarding the necessity and sufficiency of dysfunctional activation in the sexual desire and self-referential brain networks, whose answers bear on the development and evaluation of personalized treatments for HSDD.
机译：介绍：神经影像学的最新进展为女性性大脑提供了前所未有的窗口。单个功能磁共振成像研究的小样本和差的统计力量有限，可以针对涉及女性性欲和女性性功能障碍的系统脑网络（例如，低血压性欲障碍[HSDD]）。目的：定量地确定涉及HSDD的大脑网络。方法：有关神经影像学文献的系统回顾综述及统计荟萃分析。主要观察措施：对功能磁共振成像研究的发表文献审查，说明与女性性欲和女性HSDD相关的脑区域。结果：HSDD与特定的前肢 - 顶叶功能障碍有关，其特征在于（i）性欲脑网络中的低血氧水平依赖性响应和（ii）在自信脑网络中的高血氧水平依赖性响应。结论：荟萃分析结果符合HSDD的自上而下的神经功能模型，其中检测，监测和评估性活动之前或期间的性欲（而不是感官经验）干扰性欲。这些结果提出了关于性欲和自我引用脑网络中功能失调激活的必要性和充分性的新问题，其答案承担了对HSDD个性化治疗的发展和评估。

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