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首页> 外文期刊>SIAM journal on applied dynamical systems >Modeling Microtubule-Based Transport and Anchoring of mRNA
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Modeling Microtubule-Based Transport and Anchoring of mRNA

机译：基于微管的运输和MRNA锚固

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Localization of messenger RNA (mRNA) at the vegetal cortex plays an important role in the early development of Xenoyas laevis oocytes. While it is known that molecular motors are responsible for the transport of mRNA cargo along microtubules to the cortex, the mechanisms of localization remain unclear. We model cargo transport along microtubules using partial differential equations with spatially dependent rates. A theoretical analysis of reduced versions of our model predicts effective velocity and diffusion rates for the cargo and shows that randomness of microtubule networks enhances effective transport. A more complex model using parameters estimated from fluorescence microscopy data reproduces the time and spatial scales of mRNA localization observed in Xenoyas oocytes, corroborates experimental hypotheses that anchoring may be necessary to achieve complete localization, and shows that anchoring of mRNA complexes actively transported to the cortex is most effective in achieving robust accumulation at the cortex.
机译：植物皮层的信使RNA（mRNA）的定位在Xenoyas Laevis卵母细胞的早期发展中发挥着重要作用。虽然已知分子马达负责沿着微管沿微管送到皮质的虽然将mRNA货物运输，但定位的机制仍然不清楚。我们使用具有空间依赖率的部分微分方程模型沿着微管沿着微管进行模型。我们模型的降低版本的理论分析预测了货物的有效速度和扩散速率，并表明微管网络随机性增强了有效的运输。使用从荧光显微镜数据估计的参数的更复杂的模型再现在Xenoyas卵母细胞中观察到mRNA定位的时间和空间尺度，证实了锚定的实验假设，以实现完全定位，并表明MRNA复合物的锚固主动地运输到皮质上最有效地在皮质上实现鲁棒积累。

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