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首页> 外文期刊>Sexually Transmitted Infections >Dual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso
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Dual screen and confirm rapid test does not reduce overtreatment of syphilis in pregnant women living in a non-venereal treponematoses endemic region: a field evaluation among antenatal care attendees in Burkina Faso

机译：双筛网并确认快速测试不会减少孕妇的孕妇在孕妇中的梅毒进行过度治疗地方性区域：Burkina Faso的产前护理与会者的田间评估

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In resource-limited settings, screening pregnant women for syphilis using rapid diagnostic tests (RDTs) is a key tool in the prevention of congenital syphilis. However, most syphilis RDTs detect only treponemal antibodies (T-RDT), meaning antibiotics may be provided unnecessarily to previously treated pregnant women, particularly in non-venereal treponematoses endemic regions. We estimated the potential reduction in overtreatment when comparing T-RDT (SD Bioline) to a newer rapid test (Dual Path Platform (DPP) Screen and Confirm Assay, Chembio) detecting both treponemal and non-treponemal antibodies.Pregnant women in Déou, Burkina Faso, screened for syphilis during antenatal care (ANC) visits were prospectively enrolled in the study after providing consent. DPP and T-RDT tests were performed on whole blood specimens. Plasma was tested in an international reference laboratory by Treponema pallidum passive particle agglutination (TPPA) and quantitative rapid plasma reagin (RPR). Presumptive active syphilis was defined as a result that was both TPPA and RPR reactive.Of the 242 pregnant women included in the study, 91 (37.6%) had presumptive active syphilis and 19.0% had RPR titres ≥8. DPP testing did not reduce the number of pregnant women who would have been overtreated compared with T-RDT (0.0% vs 2.5%; p=0.218) and had a higher proportion of underdiagnosis (48.4% vs 2.2%; p<0.001). Seven women with high RPR titres ≥8 would not have received treatment had only DPP testing been used.In the first evaluation comparing DPP with traditional screening methods in pregnant women, we saw no reduction in unnecessarily treated syphilis and an underestimation of those needing treatment. High seroprevalence in the population may indicate the presence of other treponemal infections in the area, and further study of DPP in a variety of Sahelian and other contexts is warranted.
机译：在资源限制的环境中，使用快速诊断测试（RDT）筛选孕妇进行梅毒（RDT）是预防先天性梅毒的关键工具。然而，大多数梅毒RDT检测到仅检测葡萄糖抗体（T-RDT），这意味着可以不必要地提供抗生素，以预先治疗孕妇，特别是在非Venereal蜂鸣中的地方性区域。在将T-RDT（SD Bioline）与较新的快速测试（双路径平台（DPP）筛选和确认测定，ChemBio）进行比较时，我们估计过度变化的潜在降低了检测Treponemal和非培养型抗体。Déou，布基纳的孕妇Faso，筛选梅毒在产前护理期间（ANC）访问，在提供同意后潜入研究。 DPP和T-RDT测试在全血样本上进行。通过Treponema Pallidum被动颗粒凝集（TPPA）和定量快速等离子体射回（RPR）在国际参考实验室中测试血浆。预设的活性梅毒被定义为TPPA和RPR反应。根据该研究的242名孕妇，91名（37.6％）具有推定的活性梅毒，19.0％具有RPR滴度≥8。 DPP测试没有减少与T-RDT（0.0％Vs 2.5％; P = 0.218）相比过度处理的孕妇数量，并且欠诊断比例较高（48.4％Vs 2.2％; P <0.001）。具有高RPR滴度≥8的七个女性将没有接受治疗，只使用了DPP测试。在第一次评估中，将DPP与孕妇中的传统筛查方法进行比较，我们没有减少不必要的治疗梅毒，低估了治疗的人。人口中的高血管升压可能表明该地区存在其他剧烈感染，并有必要进一步研究DPP在各种萨赫伦和其他环境中。

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