...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>ORL: Journal for oto-rhino-laryngology and its borderlands >Topical Corticosteroids Decrease IL-25 Expression by Immunohistochemistry
【24h】

Topical Corticosteroids Decrease IL-25 Expression by Immunohistochemistry

机译：局部皮质类固醇通过免疫组化减少IL-25表达

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Interleukin-25 (IL-25) is an important contributing factor in the pathogenesis of allergic rhinitis. It leads to increasing peripheral and infiltrating eosinophilia as well as serum IgE, IgG, and Th2 cytokines (IL-4, IL-5, IL-13), which are responsible for the allergic symptoms. Intranasal steroids (INS) are effective in treating allergic rhinitis, but their effect on IL-25 release has not been studied. We aimed to study the link between IL-25 and the pathophysiology of allergic rhinitis as well as the effect of INS on its release. Methodology: This was a cohort, prospective, nonrandomized study that included 60 patients, 35 allergic rhinitis patients and 25 controls. We studied the effect of INS on IL-25 release. Results: Of allergic rhinitis patients 68.6% had strong cytoplasmic stain of IL-25 in the epithelial layer, while 25.7% had intermediate stain. INS caused significantly reduced IL-25 stain as only 14.3% of patients had intermediate stain and 85.7% had weak stain. Moreover, a correlation was found between nasal smear eosinophilia and the degree of IL-25 staining in the epithelial layer. Conclusion: Intranasal corticosteroids appear to be effective in the downregulation of IL-25, which may explain some of the utility of intranasal corticosteroid treatment in improving allergic rhinitis symptoms.
机译：背景：白细胞介素-25（IL-25）是过敏性鼻炎发病机制中的重要贡献因素。它导致外周血和浸润性嗜酸性粒细胞以及血清IgE，IgG和Th2细胞因子（IL-4，IL-5，IL-13），这对过敏症状负责。鼻内类固醇（INS）有效治疗过敏性鼻炎，但它们对IL-25释放的影响尚未研究。我们旨在研究IL-25之间的联系和过敏性鼻炎的病理生理学以及INS对其释放的影响。方法论：这是一项队列，前瞻性，非扫描研究，包括60名患者，35例过敏性鼻炎患者和25例。我们研究了IN-25释放的INS的效果。结果：过敏性鼻炎患者68.6％在上皮层中具有强烈的细胞质染色，而25.7％具有中间染色。 INS显着降低IL-25污渍，只有14.3％的患者的中间染色，85.7％的污渍弱。此外，在鼻涂嗜酸性嗜酸性粒细胞和上皮层中染色的IL-25度之间发现了相关性。结论：鼻内皮质类固醇似乎在IL-25的下调方面有效，这可以解释鼻内皮质类固醇治疗在改善过敏性鼻炎症状方面的一些效用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号