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首页> 外文期刊>ORL: Journal for oto-rhino-laryngology and its borderlands >Expression of NIS, VEGF-A and Thyroid Autoantibody in Papillary Thyroid Carcinoma with or without Hashimoto's Disease
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Expression of NIS, VEGF-A and Thyroid Autoantibody in Papillary Thyroid Carcinoma with or without Hashimoto's Disease

机译：NIS，VEGF-A和甲状腺自身抗体在乳头状甲状腺癌中的表达，有或没有Hashimoto病

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Background: Since the incidence of papillary thyroid carcinoma (PTC) combined with Hashimoto's thyroiditis (HT) has increased year by year, but the mechanism is still unknown, the goal of this study was to investigate the expression of Na+/I- symporter (NIS), vascular endothelial growth factor (VEGF)-A and thyroid autoantibodies in HT combined with PTC, and to explore the relationship between HT and PTC. Methods: Real-time fluorescence quantitative polymerase chain reaction was used to detect the expression of VEGF-A and NIS in 38 cases of PTC and HT combined with PTC and in 20 cases of normal tissues; preoperative serum TPOAb and TgAb levels in each group were detected by ELISA. Results: The expression of VEGF-A in PTC and HT combined with PTC was significantly higher than that in normal tissues (p < 0.05), and the expression of VEGF-A in HT combined with PTC was higher than that in PTC (p < 0.05). The expression of NIS mRNA in PTC and HT combined with PTC was significantly decreased compared to that in normal tissues (p < 0.05), and NIS mRNA in HT combined with PTC tissue was lower than that in PTC tissue (p < 0.05). The preoperative levels of TPOAb and TgAb in the HT combined with PTC group were higher than those in the normal group and the PTC group (p < 0.05). Conclusion: The presence of HT may inhibit iodine uptake and cause a decrease in NIS. Increased levels of TPOAb and TgAb in HT patients lead to a high expression of TSH and stimulate VEGF secretion. This may explain why HT could accelerate the occurrence and development of PTC.
机译：背景：由于乳头状甲状腺癌（PTC）的发病率结合散列瘤（HT）逐年增加，但该研究仍然未知，本研究的目标是探讨NA + / I- Symporter的表达（NIS ），HT中的血管内皮生长因子（VEGF）-A和甲状腺自身抗体与PTC结合，探讨HT和PTC之间的关系。方法：使用实时荧光定量聚合酶链式反应检测38例PTC和HT结合PTC和20例正常组织中VEGF-A和NIS的表达; ELISA检测每组术前血清TPOAB和TGAB水平。结果：VEGF-A在PTC和HT中的表达与PTC相结合显着高于正常组织（P <0.05），HT中的VEGF-A与PTC结合的表达高于PTC（P <） 0.05）。与正常组织（P <0.05）中的PTC和HT结合PTC中NIS mRNA在PTC中的表达显着降低，并且HT中的NIS mRNA与PTC组织组合低于PTC组织中的（P <0.05）。 HT中的TPOAB和TGAB的术前水平与PTC组合并的高于正常组和PTC组中的水平（P <0.05）。结论：HT的存在可能抑制碘摄取并导致NIS降低。 HT患者中TPOAB和TGAB水平增加导致TSH的高表达和刺激VEGF分泌。这可以解释为什么HT可以加速PTC的发生和发展。

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