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首页> 外文期刊>Sports health >Targeted Treatment Protocol in Patellofemoral Pain: Does Treatment Designed According to Subgroups Improve Clinical Outcomes in Patients Unresponsive to Multimodal Treatment?
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Targeted Treatment Protocol in Patellofemoral Pain: Does Treatment Designed According to Subgroups Improve Clinical Outcomes in Patients Unresponsive to Multimodal Treatment?

机译：PatellofoMoral疼痛的靶向治疗方案：根据亚组设计的治疗改善患者对多式化治疗的临床结果吗？

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Background: Targeted intervention for subgroups is a promising approach for the management of patellofemoral pain. Hypothesis: Treatment designed according to subgroups will improve clinical outcomes in patients unresponsive to multimodal treatment. Study Design: Prospective crossover intervention. Methods: Patients with patellofemoral pain (PFP; n = 61; mean age, 27 +/- 9 years) were enrolled. Patients with PFP received standard multimodal treatment 3 times a week for 6 weeks. Patients not responding to multimodal treatment were then classified into 1 of 3 subgroups (strong, weak and tight, and weak and pronated foot) using 6 simple clinical tests. They were subsequently administered 6 further weeks of targeted intervention, designed according to subgroup characteristics. Visual analog scale (VAS), perception of recovery scale (PRS), 5-Level European Quality 5 Dimensions (EQ-5D-5L), and self-reported version of the Leeds Assessment of Neuropathic Symptoms and Signs scale (S-LANSS) were used to assess pain, knee function, and quality of life before and after the interventions. Results: In total, 34% (n = 21) of patients demonstrated recovery after multimodal treatment. However, over 70% (n = 29/40) of nonresponders demonstrated recovery after targeted treatment. The VAS, PRS, S-LANSS, and EQ-5D-5L scores improved significantly after targeted intervention compared with after multimodal treatment (P < 0.001). The VAS score at rest was significantly lower in the "weak and pronated foot" and the "weak and tight" subgroups (P = 0.011 and P = 0.008, respectively). Posttreatment pain intensity on activity was significantly lower in the "strong" subgroup (P = 0.006). Conclusion: Targeted treatment designed according to subgroup characteristics improves clinical outcomes in patients unresponsive to multimodal treatment.
机译：背景：针对亚群的目标干预是一种有希望的髌古术疼痛的方法。假设：根据亚组设计的治疗将改善对患者无反应多式化治疗的临床结果。研究设计：前瞻性交叉干预。方法：Patelloforal疼痛的患者（PFP; n = 61;平均年龄，27 +/- 9岁）。 PFP患者每周3次接受标准多模态治疗3周。然后使用6种简单的临床试验，无应对多式化治疗的患者患者分为3个亚组（强，弱，紧密，弱，脚的脚部）。随后在亚组特征设计的目标干预的6周内施用6周。视觉模拟规模（VAS），回收量表（PRS），5级欧洲质量5维度（EQ-5D-5L），以及自我报告的LEEDS评估神经病症状和迹象表（S-LANS）用于评估干预措施前后的疼痛，膝关节和生活质量。结果：总共34％（n = 21）患者在多式化治疗后呈现恢复。然而，超过70％（n = 29/40）的无应答者在靶向治疗后显示出恢复。与多式化处理相比，VAS，PRS，S-LANS和EQ-5D-5L和EQ-5D-5L分数明显改善（P <0.001）。静止的VAS得分在“弱和2英尺”中显着较低，“弱和紧密”亚组（P = 0.011和P = 0.008）。 “强”亚组的活性疼痛强度显着降低（P = 0.006）。结论：根据亚组特征设计的靶向治疗改善了对多式化治疗无反应迟钝的患者的临床结果。

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