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Biological Therapies in Regenerative Sports Medicine

机译：再生运动医学的生物疗法

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摘要

Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action. We performed a literature search up to January 2016 searching for clinical outcomes following the use of cell therapies for sports conditions, tendons, and joints. The safety and efficacy of cell therapies for tendon conditions was examined in nine studies involving undifferentiated and differentiated ( skin fibroblasts, tenocytes) cells. A total of 54 studies investigated the effects of mesenchymal stem-cell ( MSC) products for joint conditions including anterior cruciate ligament, meniscus, and chondral lesions as well as osteoarthritis. In 22 studies, cellular products were injected intra-articularly, whereas in 32 studies MSC products were implanted during surgical/arthroscopic procedures. The heterogeneity of clinical conditions, cellular products, and approaches for delivery/implantation make comparability difficult. MSC products appear safe in the short- and midterm, but studies with a long follow-up are scarce. Although the current number of randomized clinical studies is low, stem-cell products may have therapeutic potential. However, these regenerative technologies still need to be optimized.
机译：再生药物寻求利用细胞生物学的潜力进行组织替代疗法，这将恢复丢失的组织功能。控制和增强组织愈合不仅仅是细胞的问题，也不是分子和机械力。我们首先描述了促进肌肉骨骼愈合的主要生物技术，包括骨髓和皮下脂肪衍生的再生产品，以及富含血小板的血浆和条件培养基。我们提供一些信息描述可能的行动机制。我们在2016年1月进行了一个文献搜索搜索使用细胞疗法，肌腱和关节使用细胞疗法后寻找临床结果。在涉及未分化和分化（皮肤成纤维细胞，Tenocytes）细胞的九项研究中检查细胞疗法的安全性和有效性。共有54项研究研究了间充质干细胞（MSC）产品对关节条件的影响，包括前十字韧带，弯月面和骨髓病变以及骨关节炎。在22项研究中，细胞产物术中注射，而在32项研究中，在手术/关节镜手术过程中植入MSC产物。临床病症，细胞产物的异质性，用于递送/植入的方法使得可比性困难。 MSC产品在短期和中期似乎安全，但长期随访的研究是稀缺的。虽然当前的随机临床研究是低，但干细胞产物可能具有治疗潜力。但是，这些再生技术仍然需要优化。

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  • 来源
    《Sports medicine》 |2017年第5期|共22页
  • 作者

    Andia Isabel; Maffulli Nicola;

  • 作者单位

    Cruces Univ Hosp BioCruces Hlth Res Inst Regenerat Med Lab Pza Cruces 12 Baracaldo 48903 Spain;

    Univ Salerno Dept Musculoskeletal Disorders Sch Med &

    Dent Salerno Italy;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 运动医学;
  • 关键词

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