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首页> 外文期刊>Stem cell reviews and Reports >Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives
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Mesenchymal Stem/Progenitor Cells Derived from Articular Cartilage, Synovial Membrane and Synovial Fluid for Cartilage Regeneration: Current Status and Future Perspectives

机译：用于软骨再生的关节软骨，滑膜和滑液的间充质茎/祖细胞：当前状态和未来的观点

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摘要

Large articular cartilage defects remain an immense challenge in the field of regenerative medicine because of their poor intrinsic repair capacity. Currently, the available medical interventions can relieve clinical symptoms to some extent, but fail to repair the cartilaginous injuries with authentic hyaline cartilage. There has been a surge of interest in developing cell-based therapies, focused particularly on the use of mesenchymal stem/progenitor cells with or without scaffolds. Mesenchymal stem/progenitor cells are promising graft cells for tissue regeneration, but the most suitable source of cells for cartilage repair remains controversial. The tissue origin of mesenchymal stem/progenitor cells notably influences the biological properties and therapeutic potential. It is well known that mesenchymal stem/progenitor cells derived from synovial joint tissues exhibit superior chondrogenic ability compared with those derived from non-joint tissues; thus, these cell populations are considered ideal sources for cartilage regeneration. In addition to the progress in research and promising preclinical results, many important research questions must be answered before widespread success in cartilage regeneration is achieved. This review outlines the biology of stem/progenitor cells derived from the articular cartilage, the synovial membrane, and the synovial fluid, including their tissue distribution, function and biological characteristics. Furthermore, preclinical and clinical trials focusing on their applications for cartilage regeneration are summarized, and future research perspectives are discussed.
机译：由于其内在修复能力差，大关节软骨缺陷仍然是再生医学领域的巨大挑战。目前，可用的医疗干预措施可以在一定程度上缓解临床症状，但未能使用正宗的透明软骨修复软骨损伤。在显影基于细胞的疗法中，特别关注的是，特别是在用或没有支架的情况下使用间充质茎/祖细胞的使用。间充质茎/祖细胞是有前途的接枝细胞，用于组织再生，但软骨修复的最合适的细胞来源仍然存在争议。间充质茎/祖细胞的组织起源显着影响生物学性质和治疗潜力。众所周知，与从非关节组织衍生的那些相比，来自滑膜关节组织的间充质茎/祖细胞具有优异的软骨内能力;因此，这些细胞群被认为是软骨再生的理想来源。除了研究和有前途的临床前结果外，必须在达到软骨再生的广泛成功之前应答许多重要的研究问题。该审查概述了源自关节软骨，滑膜膜和滑膜液的茎/祖细胞的生物学，包括它们的组织分布，功能和生物学特性。此外，概述了专注于其软骨再生应用的临床前和临床试验，并讨论了未来的研究观点。

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