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Human brain MRI at 500MHz, scientific perspectives and technological challenges

机译:人脑MRI在500MHz,科学的观点和技术挑战

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The understanding of the human brain is one of the main scientific challenges of the 21st century. In the early 2000s the French Alternative Energies and Atomic Energy Commission launched a program to conceive and build a 'human brain explorer', the first human MRI scanner operating at 11.7 T. This scanner was envisioned to be part of the ambitious French-German project Iseult, bridging together industrial and academic partners to push the limits of molecular neuroimaging, from mouse to man, using ultra-high field MRI. In this article we provide a summary of the main neuroscience and medical targets of the Iseult project, mainly to acquire within timescales compatible with human tolerances images at a scale of 100 mu m at which everything remains to discover, and to create new approaches to develop new imaging biomarkers for specific neurological and psychiatric disorders. The system specifications, the technological challenges, in terms of magnet design, winding technology, cryogenics, quench protection, stability control, and the solutions which have been chosen to overcome them and build this outstanding instrument are provided. Lines of the research and development which will be necessary to fully exploit the potential of this and other UHF MRI scanners are also outlined.
机译:对人类大脑的理解是21世纪的主要科学挑战之一。在2000年代初,法国替代能源和原子能委员会启动了一个设想并建立了“人脑探险家”的计划,这是在11.7 T期间运行的第一人体MRI扫描仪。该扫描仪被设想成为雄心勃勃的法语 - 德国项目的一部分Iseult,桥接工业和学术伙伴,以利用超高场MRI从小鼠到人的分子神经影像动物的限制。在本文中,我们提供了Iseult项目的主要神经科学和医疗目标的摘要,主要是在与人类容忍图像兼容的时间尺寸,以100亩的群体仍然存在,并创造新的发展方法。新的成像生物标志物,用于特异性神经系统和精神病症。提供了系统规范,技术挑战,在磁铁设计,绕组技术,低温,淬火保护,稳定性控制和选择克服它们的解决方案方面,提供了克服它们的解决方案。还概述了完全利用这一潜力和其他UHF MRI扫描仪所必需的研究和发展的线条。

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