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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Relationship between circadian activity rhythms and fatigue in hospitalized children with CNS cancers receiving high-dose chemotherapy
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Relationship between circadian activity rhythms and fatigue in hospitalized children with CNS cancers receiving high-dose chemotherapy

机译：CNS癌症接受高剂量化疗的住院儿童昼夜活动节奏与疲劳的关系

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Purpose Robust circadian rhythms are increasingly recognized as essential to good health. Adult cancer patients with dysregulated circadian activity rhythms (CAR) experience greater fatigue, lower responsiveness to chemotherapy, and shorter time to relapse. There is scant research describing circadian rhythms and associated outcomes in children with cancer. As part of a larger study examining whether a cognitive-behavioral intervention could preserve sleep in children and adolescents with central nervous system cancers hospitalized for high-dose chemotherapy (HDCT), this study aimed to compare CAR of these children to published values and to investigate the relationship between CAR and fatigue. Methods Participants aged 4-19 years wore an actigraph throughout their hospitalization (5 days). From activity counts recorded by actigraphy, six CAR variables were calculated: amplitude, 24-h autocorrelation (r24), dichotomy index (I < O), interdaily stability (IS), intradaily variability (IV), and acrophase. Parent-reported child fatigue and child/adolescent self-reported fatigue measures were collected daily. Results Thirty-three participants were included. Three CAR variables (amplitude, r24, and I < O) showed dysregulation compared to published values. Older age was significantly associated with later acrophase and greater dysregulation of all other CAR variables. Controlling for age, more dysregulated amplitude (p = 0.001), r24 (p = 0.003), IS (p = 0.017), and IV (p = 0.001) were associated with higher parent-reported fatigue; more dysregulated IV (p = 0.003) was associated with higher child-reported fatigue. Conclusions Participants demonstrated dysregulated CAR during hospitalization for HDCT. Greater dysregulation was associated with greater fatigue. Research on circadian dysregulation and its relationship to health-related outcomes in children with cancer, and interventions to support circadian rhythmicity, is urgently needed.
机译：目的强大的昼夜节律越来越被认为是健康的至关重要。成人癌症患者患有失调的昼夜活动节奏（汽车）体验更大的疲劳，对化疗的响应性降低，复发时间较短。有很少的研究，描述了癌症的昼夜节律和相关成果。作为较大研究的一部分，检查是否可以在患有用于高剂量化疗（HDCT）的中枢神经系统癌症的儿童和青少年中是否可以保护儿童和青少年的患者，这项研究旨在将这些儿童的汽车与公布的价值观进行比较并调查汽车与疲劳之间的关系。方法参与者4-19岁，在他们住院期间穿着占空票（5天）。从激光记录的活动计数，计算六个轿厢变量：幅度，24小时自相关（R24），二分法指数（I

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