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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Symptom response analysis of a randomized controlled trial of reflexology for symptom management among women with advanced breast cancer
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Symptom response analysis of a randomized controlled trial of reflexology for symptom management among women with advanced breast cancer

机译：患有先进乳腺癌患者症状管理的随机对照试验的症状响应分析

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Purpose To examine symptom responses resulting from a home-based reflexology intervention delivered by a friend/family caregivers to women with advanced breast cancer undergoing chemotherapy, targeted, and/or hormonal therapy. Methods Patient-caregiver dyads (N = 256) were randomized to 4 weekly reflexology sessions or attention control. Caregivers in the intervention group were trained by a reflexology practitioner in a 30-min protocol. During the 4 weeks, both groups completed telephone symptom assessments using the M. D. Anderson Symptom Inventory. Those who completed at least one weekly call were included in this secondary analysis (N = 209). Each symptom was categorized as mild, moderate, or severe using established interference-based cut-points. Symptom response meant an improvement by at least one category or remaining mild. Symptom responses were treated as multiple events within patients and analyzed using generalized estimating equations technique. Results Reflexology was more successful than attention control in producing responses for pain (OR = 1.84, 95% CI (1.05, 3.23), p = 0.03), with no significant differences for other symptoms. In the reflexology group, greater probability of response across all symptoms was associated with lower number of comorbid condition and lower depressive symptomatology at baseline. Compared to odds of responses on pain (chosen as a referent symptom), greater odds of symptom response were found for disturbed sleep and difficulty remembering with older aged participants. Conclusions Home-based caregiver-delivered reflexology was helpful in decreasing patient-reported pain. Age, comorbid conditions, and depression are potentially important tailoring factors for future research and can be used to identify patients who may benefit from reflexology.
机译：目的研究由朋友/家庭护理人员提供的家庭反射症干预所产生的症状响应，该症状由高级乳腺癌进行化疗，靶向和/或荷尔蒙治疗的女性。方法将患者 - 护理人员（N = 256）（n = 256）随机化至4周重视学会或注意力控制。干预组中的护理人员在30分钟的协议中被反射科从业者培训。在4周内，两组均使用M. D. Anderson症状库存完成了电话症状评估。完成至少一个每周呼叫的人被列入该次要分析（n = 209）。使用建立的基于干扰的切割点，将每个症状分类为轻度，中等或严重。症状响应意味着至少一个类别或剩余的温和改善。症状应答被视为患者内的多种事件，并使用广义估计方程技术进行分析。结果反射疗法比注意疼痛的反应更成功（或= 1.84,95％CI（1.05,3.23），P = 0.03），对其他症状没有显着差异。在反射液组中，所有症状响应的更大概率与较少数量的合并症病症和基线下降抑郁症状有关。与对疼痛的反应的几率相比（被选择为参考症状），发现症状响应的症状响应的几率令人不安，并且与老年人的老年参与者难以记住。结论家庭护理人员交付的反射疗法有助于降低患者报告的疼痛。年龄，合并症条件和抑郁症是未来研究的潜在重要的定制因素，可用于识别可能受益于反射学的患者。

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