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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >The burden of low anterior resection syndrome on quality of life in patients with mid or low rectal cancer
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The burden of low anterior resection syndrome on quality of life in patients with mid or low rectal cancer

机译：低前切除综合征对中低直肠癌患者生活质量的负担

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Background Low anterior resection (LAR) with total mesorectal excision (TME) for mid and low rectal cancer is standard of care, reducing local recurrence and enhancing long-term survival. However, this surgery is associated with a constellation of major defecatory problems that are collectively referred to as low anterior resection syndrome (LARS). The aims of this study were to evaluate the frequency of LARS in patients who have undergone LAR and to assess the impact of LARS on long-term quality of life (QoL). Methods This was a single-center prospective survey study on patients who underwent LAR and TME for low or mid rectal cancer between 2007 and 2015. LARS score and QLQ-C30 questionnaires were used to evaluate patient's bowel functions and quality of life, respectively. Associations between LARS and QoL were evaluated. Results Fifty-seven patients out of 65 eligible agreed to participate in the study. Forty-three (66%) patients returned complete questionnaires. Five patients (11.6%) had no LARS, 7 had minor LARS (16.3%), and 31 had major LARS (72.1%). In univariate analysis, BMI > 30 kg/m(2) was predictive of major LARS (p = 0.047). Major LARS did not impair global QoL (p = 0.75), function scores, or social scales, and was not associated with any of the symptom scores except for diarrhea (p = 0.02). Conclusion LARS is a frequent occurrence after LAR and TME for rectal cancer (72.1%) and is more prevalent in morbidly obese patients. However, the occurrence of LARS does not appear to have a direct impact on QoL except for the occurrence of diarrhea.
机译：背景技术中低直肠癌总切除切除（TME）的低前切除术（TME）是护理标准，降低局部复发并增强长期存活。然而，这种手术与主要被胁迫问题的星座相关联，这些问题被统称为低前切除术综合征（Lars）。本研究的目的是评估经历了大量的患者的LARS的频率，并评估Lars对长期生活质量（QOL）的影响。方法这是2007年至2015年间直肠癌患者的单中心前瞻性调查研究，患有低调或中直肠癌的患者.RARS得分和QLQ-C30问卷分别用于评估患者的肠功能和生活质量。评估LAR和QOL之间的关联。结果65名患者的57名患者符合参加的研究。四十三（66％）患者返回完整的问卷。五名患者（11.6％）没有Lars，7例患有轻微的Lars（16.3％），31个主要Lars（72.1％）。在单变量分析中，BMI> 30kg / m（2）预测主要Lars（P = 0.047）。主要LARS不损害全球QOL（P = 0.75），功能评分或社会尺度，并且与除腹泻外的任何症状分数无关（P = 0.02）。结论Lars频繁发生，直肠癌（72.1％）后，在病态肥胖患者中更为普遍。然而，除了发生腹泻的发生之外，Lars的发生并不直接影响QoL。

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