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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy—a controlled feasibility trial
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Resistance training as supportive measure in advanced cancer patients undergoing TKI therapy—a controlled feasibility trial

机译：抗性培训作为高级癌症患者的支持措施，接受TKI治疗 - 一种受控可行性试验

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Abstract Purpose While there is growing evidence for positive effects of progressive resistance training in curatively treated cancer patients, data on advanced cancer patients are scarce. This pilot study aimed at investigating for the first time feasibility and effects of progressive resistance training in advanced cancer patients undergoing tyrosine kinase inhibitor (TKI) therapy. Methods Patients starting a TKI-based anti-tumor therapy were assigned to a resistance training group (RT, 12?weeks of progressive machine-based resistance training 2×/week) or a control group (CON, treatment as usual) until 10 patients had finished in each group (RT 80% males, 90% renal cell carcinoma, 65?±?11?years, CON 80% males, 70% renal cell carcinoma, 61?±?6?years). Primary endpoint was feasibility. Furthermore, fatigue (MFI), quality of life (QoL, EORTC QLQC30), and muscle strength were assessed. Testing occurred at baseline and after 12?weeks. Results Training was feasible in 9 out of 10 participants and no serious adverse events occurred. It had beneficial effects on muscle strength (maximum voluntary isometric contraction of the quadriceps: RT +11?±?9?Nm, CON ?13?±?25?Nm, p ?=?0.005), but not on fatigue (general fatigue score RT +0.3?±?4.1, CON -1.5?±?3.0, p ?=?0.223) or QoL (global QoL score RT ?5.6?±?16.1, CON ?2.0?±?18.2, p ?=?0.617). Conclusions Progressive machine-based resistance training appears feasible in the majority of advanced cancer patients undergoing TKI therapy. However, its positive effects on muscle strength do not seem to be associated with positive effects on fatigue or quality of life. Future studies should therefore compare whether home-based training is more beneficial for patient-reported outcomes. Trial registration NCT01645150
机译：摘要目的虽然存在渐进式抗性抗性培训患者积极影响的证据，但晚期癌症患者的数据稀缺。该试点研究旨在调查术治疗酪氨酸激酶抑制剂（TKI）治疗的晚期癌症患者渐进性抗性训练的第一次可行性和影响。方法将患者患者分配给抗TKI的抗肿瘤治疗的抗性训练组（RT，12个逐步的基于机的电阻训练2×/周）或对照组（常规治疗）直到10名患者已经完成每组（RT 80％雄性，90％肾细胞癌，65°？±11？年，CON 80％雄性，70％肾细胞癌，61？±6？岁）。主要端点是可行性的。此外，评估疲劳（MFI），寿命质量（QOL，EORTC QLQC30）和肌肉强度。测试发生在基线和12周后。结果培训在10名参与者中有9人可行，并且没有发生严重的不良事件。它对肌肉力量有益的影响（Quadriceps的最大自愿等距收缩：RT +11？±9？9？NM，CON？13？±25？NM，P？= 0.005），但不是疲劳（一般疲劳得分Rt + 0.3？±4.1，Con -1.5？±3.0，P？=？0.223）或QOL（全球QOL得分Rt？5.6？±16.1，Con？2.0？±？18.2，P？= 0.617 ）。结论大多数晚期癌症患者的进步癌症患者的逐步癌症患者似乎可行。然而，它对肌肉力量的积极影响似乎与对疲劳或生活质量的积极影响有关。因此，未来的研究应该比较家庭培训对患者报告的结果更有益。试验登记NCT01645150.

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