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首页> 外文期刊>Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer >Long-term prognosis of septic shock in cancer patients
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Long-term prognosis of septic shock in cancer patients

机译：癌症患者脓毒症休克的长期预后

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Objectives In the last decades, the number of cancer patients admitted in intensive care units (ICUs) for septic shock has dramatically increased. However, prognosis data remain scarce. Methods To assess the 180-day mortality rate in cancer patients admitted to the ICU for septic shock, a 5-year prospective study was performed. All adult patients admitted for septic shock were included and categorized into the following two groups and four subgroups: cancer patients (solid tumor or hematological malignancy) and non-cancer patients (immunocompromised or not). Data were collected and compared between the groups. Upon early ICU admission, the decision to forgo life-sustaining therapy (DFLST) or not was made by consultation among hematologists, oncologists, and the patients or their relatives. Results During the study period, 496 patients were admitted for septic shock: 252 cancer patients (119 hematological malignancies and 133 solid tumors) and 244 non-cancer patients. A DFLST was made for 39% of the non-cancer patients and 52% of the cancer patients. The 180-day mortality rate among the cancer patients was 51% and 68% for those with hematological malignancies and solid cancers, respectively. The mortality rate among the non-cancer patients was 44%. In a multivariate analysis, the performance status, Charlson comorbidity index, simplified acute physiology score 2, sequential organ failure assessment score, and DFLST were independent predictors of 180-day mortality. Conclusions Despite early admission to the ICU, the 180-day mortality rate due to septic shock was higher in cancer patients compared with non-cancer patients, due to excess mortality in the patients with solid tumors. The long-term prognosis of cancer patients with septic shock is modulated by their general state, severity of organ failure, and DFLST.
机译：目的在过去几十年中，对脓毒症休克的重症监护单位（ICU）承认的癌症患者的数量显着增加。但是，预后数据仍然稀缺。评估癌症患者180日死亡率的方法，患上脓毒症休克，进行了5年的前瞻性研究。所有参加脓毒性休克的成年患者被包括在内，并分为以下两组和四个亚组：癌症患者（实体肿瘤或血液恶性肿瘤）和非癌症患者（免疫抑制或不）。收集数据并在组之间进行比较。早期ICU入院后，决定饲养寿命维持治疗（DFLST）或不是通过血液学师，肿瘤学家和患者或其亲属的咨询来制作的。结果在研究期间，496名患者因脓毒症休克而入院：252名癌症患者（119例血液恶性肿瘤和133种实体肿瘤）和244名非癌症患者。 DFLST为39％的非癌症患者和52％的癌症患者制作。患有血液恶性恶性肿瘤和固体癌症的人的180日死亡率为51％和68％。非癌症患者之间的死亡率为44％。在多变量分析中，性能状态，Charlson合并症指数，简化的急性生理学评分2，顺序器官失败评估评分和DFLST是180天死亡率的独立预测因子。结论尽管早期入院ICU，但由于患有实体肿瘤的患者的死亡率过高，癌症患者引起的180日死亡率较高。癌症休克患者的长期预后通过它们的一般状态调节，器官衰竭和DFLST的严重程度。

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