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Preface

机译:前言

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摘要

Gastrointestinal pathology emerged as a sub-specialty in the early 1980s, roughly coincident with development of endoscopy and mucosal biopsy for diagnosis and management of patients with gastrointestinal disorders. Since that time, changes in tissue acquisition techniques and ancillary testing have drastically altered the field, such that current practice bears little resemblance to that of our mentors. The past two decades have seen an explosion in the number and types of biopsy samples pathologists encounter in daily practice. Virtually every part of the tubular gut is now amenable to visualization and sampling. As a result, pathologists are expected to generate comprehensive and accurate differential diagnoses for a variety of inflammatory and neoplastic disorders that occur throughout the gastrointestinal tract. Although we have always played an important role in the care of patients with persistent gastrointestinal symptoms, we are increasingly involved in the management of immunosuppressed patients, particularly those with hematopoietic malignancies receiving stem cell transplants. Most of these individuals require medical therapies notorious for their negative effects on the gastrointestinal tract. Unfortunately, immune-mediated injury, infections, and medication effects are common in this population and evoke similar patterns of mucosal damage in biopsy material. Pathologists must be able to hone in on key features in order to narrow the differential diagnosis and facilitate patient management.
机译:胃肠道病理成为20世纪80年代初的亚特色,大致与内窥镜检查和粘膜活检的发展致诊断和管理胃肠道疾病的诊断和管理。从那时起,组织采集技术和辅助测试的变化大大改变了该领域,使得当前的实践与我们的导师的相似性很少。过去二十年已经看到了活检样本的数量和类型的爆炸性,病理学家在日常实践中遇到。实际上,管状肠道的每个部分现在都适用于可视化和抽样。结果,预计病理学家将为整个胃肠道发生的各种炎症和肿瘤疾病产生全面和准确的差异诊断。虽然我们一直在关心患有持续胃肠道症状的患者中发挥重要作用,但我们越来越多地参与免疫抑制患者的管理,特别是那些接受干细胞移植物的造血恶性肿瘤的患者。这些人中的大多数都需要医疗疗法对胃肠道的负面影响臭味。不幸的是,免疫介导的损伤,感染和药物效应在该群中常见,并唤起活组织检查材料中的粘膜损伤类似模式。病理学家必须能够磨练关键特征,以缩小差异诊断并促进患者管理。

著录项

  • 来源
    《Surgical pathology clinics》 |2017年第4期|共2页
  • 作者

    Rhonda K. Yantiss;

  • 作者单位

    Department of Pathology and Laboratory Medicine Weill Cornell Medicine 525 East 68th Street New;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 病理学;
  • 关键词

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