Human Papilloma Virus-Associated Squamous Neoplasia of the Lower Anogenital Tract

Eric J. Yang

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Human Papilloma Virus-Associated Squamous Neoplasia of the Lower Anogenital Tract

机译：人乳头瘤病毒相关的下源性鳞状肿瘤肿瘤瘤

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HPV-associated squamous neoplasias of the lower anogenital tract are biologically and morphologically equivalent; a unified, two-tiered nomenclature system is recommended to reflect this. Low-grade squamous intraepithelial lesion represents the morphologic manifestation of transient HPV infection with high rate of regression. High-grade squamous intraepithelial lesion (HSIL) represents the morphologic manifestation of persistent high-risk HPV infection and viral integration with a significant rate of progression to invasive carcinoma. Despite these shared attributes, SILs encounter unique diagnostic challenges by anatomic site. This article discusses the LAST project recommendations, challenges associated with their application, and site specific diagnostic challenges in their relevant clinical context.

机译：HPV相关的下胃部道的鳞状肿瘤瘤是生物学上和形态的等同物; 建议统一双层的命名系统来反映这一点。低级鳞状上皮病变代表了高回归速率瞬态HPV感染的形态学表现。高级鳞状上皮内病变（HSIL）代表了持续高风险HPV感染和病毒整合的形态表现，具有侵入性癌的显着进展速率。尽管有这些共享属性，SILS遇到了解剖网站的独特诊断挑战。本文讨论了上次项目建议，与其应用相关的挑战，以及在其相关临床环境中的特定诊断挑战。

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来源
《Surgical pathology clinics》 |2019年第2期|共17页
作者
Eric J. Yang;
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作者单位

Department of Pathology Stanford University School of Medicine 300 Pasteur Drive H2128B Stanford;

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原文格式 PDF
正文语种 eng
中图分类病理学;
关键词
Human papillomavirus (HPV); Low-grade squamous intraepithelial lesion (LSIL); High-grade squamous intraepithelial lesion (HSIL); Dysplasia; Squamous cell carcinoma; Lower anogenital tract;

机译：人乳头瘤病毒（HPV）;低级鳞状上皮内病变（LSIL）;高档鳞状上皮内病变（HSIL）;发育不良;鳞状细胞癌;低胃癌;

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专利

1. Human Papilloma Virus-Associated Squamous Neoplasia of the Lower Anogenital Tract [J] . Eric J. Yang Surgical pathology clinics . 2019,第2期

机译：人乳头瘤病毒相关的下源性鳞状肿瘤肿瘤瘤
2. HPV-related Squamous Neoplasia of the Lower Anogenital Tract: An Update and Review of Recent Guidelines (vol 21, pg 341, 2014) [J] . Maniar K. P., Nayar R. Advances in anatomic pathology . 2015,第2期

机译：HPV相关的下肛门生殖道鳞状鳞癌：最新指南的更新和审查（第21卷，第341页，2014年）
3. HPV-related squamous neoplasia of the lower anogenital tract: An update and review of recent guidelines [J] . Advances in anatomic pathology . 2014,第5期

机译：HPV相关性下生殖道鳞状上皮瘤变：最新指南的更新和回顾
4. Protein differences associated with human papilloma virus status in oropharyngeal squamous cell carcinoma (OSCC) [C] . Nico Jehmlich, Brandee Brown, Wendell G. Yarbrough, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：与口咽鳞状细胞癌（OSCC）中的人乳头瘤病毒状态相关的蛋白质差异
5. Morphological and biochemical mechanisms linked to the development of papilloma-independent metastatic squamous cell carcinoma in PKC epsilon overexpression transgenic mice. [D] . Li, Yafan. 2005

机译：形态和生化机制与在PKC epsilon过表达转基因小鼠中不依赖乳头状瘤的转移性鳞状细胞癌的发展有关。
6. Human papilloma virus-associated metachronous squamous cell carcinoma of the larynx and uterine cervix: Case report and review of the literature [O] . Semiramis Carbajal-Mamani, Neil Chheda, Ashwini Esnakula, 2020

机译：人乳头瘤病毒相关的喉癌和子宫颈病毒鳞状细胞癌：案例报告和文学审查
7. Ezrin–Radixin–Moesin Binding Phosphoprotein 50: A Potential Novel Biomarker in Human Papilloma Virus-Associated Head and Neck Squamous Cell Carcinomas [O] . Athiva Shankar, Dorothy H. Crouch, Michaelina Macluskey 2018

机译：Ezrin-radixin-moesin结合磷蛋白50：一种人乳头瘤病毒相关头颈鳞状细胞癌中的潜在新型生物标志物

Human Papilloma Virus-Associated Squamous Neoplasia of the Lower Anogenital Tract

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